All Phenotypes Wwc2<tm1.1Arte> MGI Mouse

• 3-month-old mice exhibit liver overgrowth

• however, liver does not show alterations in canalicular morphology, hepatocyte ultrastructure, or hepatic plate thickness, indicating normal hepatocyte polarity

increased liver weight ( J:305034 )

• 3-month-old mice exhibit increased liver weight relative to total body weight, which is increased in 6-month-old mice and is about 5-fold higher than in controls at 12 months of age

abnormal portal triad morphology ( J:305034 )

• liver shows massive enrichment of small cells at portal triads

• liver shows malformation of the portal triads with an increase of ductal structures

• however, the arrangement of hepatic cells close to the central vein appears normal

liver fibrosis ( J:305034 )

• liver shows the presence of fibrotic areas close to portal triads and in the periportal zones

increased liver tumor incidence ( J:305034 )

• 12-month-old mice exhibit numerous liver tumors that have characteristics of both hepatocellular carcinoma and cholangiocarcinoma, possibly representing an intermediate tumor phenotype

• tumors show cells with enlarged, atypical nuclei and irregular arrangements of hepatocytes, and the border between each tumor and normal liver tissue is made up of a collagen-rich capsule

abnormal liver physiology ( J:305034 )

• 6-month-old livers show enhanced proliferation of immature biliary epithelial cell-like progenitor cells

liver inflammation ( J:305034 )

• livers show an enrichment of activated myofibroblasts and infiltration with inflammatory macrophages