All Phenotypes Impact<tm1.1Casb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Impact^tm1.1Casb/Impact^tm1.1Casb	involves: C57BL/6J	MGI:6710958
cx2	Eif2ak4^tm1Drc/Eif2ak4^tm1Drc Impact^tm1.1Casb/Impact^tm1.1Casb	involves: 129S6/SvEvTac * C57BL/6J	MGI:6710959

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:279071 )

• maintain a lean phenotype on a high fat diet

decreased fasting circulating glucose level ( J:279071 )

• after an 18h fast

• however, fed glucose levels are similar to controls

decreased body temperature ( J:279071 )

• drastically reduced after 18 hr of fasting but returns to normal after refeeding

• slightly lower body temperature in response to a cold environment but do adjust body temperature in response to a cold environment

decreased oxygen consumption ( J:279071 )

• during the dark phase

increased insulin sensitivity ( J:279071 )

• after 11 and 12 weeks on a high fat diet

adipose tissue

decreased white adipose tissue amount ( J:279071 )

• on normal chow and a high fat diet

behavior/neurological

decreased food intake ( J:279071 )

• on a high fat diet

growth/size/body

decreased body weight ( J:279071 )

decreased susceptibility to diet-induced obesity ( J:279071 )

• maintain a lean phenotype on a high fat diet

Allelic Composition	Eif2ak4^tm1Drc/Eif2ak4^tm1Drc Impact^tm1.1Casb/Impact^tm1.1Casb
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak4^tm1Drc mutation (0 available); any Eif2ak4 mutation (88 available)
Impact^tm1.1Casb mutation (0 available); any Impact mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:279071 )

• maintain a lean phenotype on a high fat diet

decreased body temperature ( J:279071 )

• reduced after 18 hr of fasting but returns to normal after refeeding

• decrease in body temperature induced by fasting is less than in Impact single homozygous mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:279071 )

• maintain a lean phenotype on a high fat diet

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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