Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem1(Tor1b)Wtd mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(dlx5a-cre)1Mekk mutation
(2 available)
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behavior/neurological
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N |
• mice show normal postnatal growth and survival, and normal juvenile reflexes, including negative geotaxis, surface righting, and forelimb hang
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem1(Tor1b)Wtd mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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growth/size/body
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• decreased body weight before P56
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behavior/neurological
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N |
• mice do not show overt motor abnormalities
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mortality/aging
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N |
• mice show normal survival
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nervous system
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N |
• brain morphology and size appear normal
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behavior/neurological
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N |
• mice show rescue of the limb clasping phenotype and the twisting movements seen in Tor1atm1Wtd/Tor1atm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice
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nervous system
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N |
• mice show prevention of striatal cholinergic interneuron degeneration that occurs in Tor1atm1Wtd/Tor1atm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice
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normal phenotype
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• mice do not exhibit lethality, growth defects, or abnormal twisting movements or stiff postures, and exhibit normal brain with no gliosis
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behavior/neurological
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N |
• mice show almost complete rescue of the abnormal postural (squinty eyes and twisted hindpaws) and development phenotypes seen in Tor1atm2Wtd/Tor1atm3.1Wtd Tg(Nes-cre)1Kln/0 mice
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growth/size/body
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N |
• mice exhibit partial rescue of the postnatal growth retardation seen in Tor1atm2Wtd/Tor1atm3.1Wtd Tg(Nes-cre)1Kln/0 mice from P8 to P28 and are fully restored to normal weight by P56
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nervous system
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N |
• mice do not exhibit neurodegeneration or gliosis
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Analysis Tools
