About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Col1a1tm1(tetO-GFP,-RNAi:Eef1a1)Mcg
targeted mutation 1, McGill University
MGI:6693286
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Col1a1tm1(tetO-GFP,-RNAi:Eef1a1)Mcg/Col1a1+
Ssttm2.1(cre)Zjh/Sst+
involves: 129S4/SvJae * C57BL/6J MGI:6693445
cn2
Col1a1tm1(tetO-GFP,-RNAi:Eef1a1)Mcg/Col1a1+
Tg(Prkcd-glc-1/CFP,-cre)EH124Gsat/0
involves: C57BL/6J * FVB/NTac MGI:6693444


Genotype
MGI:6693445
cn1
Allelic
Composition
Col1a1tm1(tetO-GFP,-RNAi:Eef1a1)Mcg/Col1a1+
Ssttm2.1(cre)Zjh/Sst+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-GFP,-RNAi:Eef1a1)Mcg mutation (0 available); any Col1a1 mutation (161 available)
Ssttm2.1(cre)Zjh mutation (4 available); any Sst mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice virally expressing a cre-dependent tet transactivator exhibit normal behavior in an open field and exploration of an elevated plus maze
• mice virally expressing a cre-dependent tet transactivator exhibit reduced long term memory in a cued threat-conditioning paradigm compared with wild-type
• however, supplementation with doxycycline rescues phenotype




Genotype
MGI:6693444
cn2
Allelic
Composition
Col1a1tm1(tetO-GFP,-RNAi:Eef1a1)Mcg/Col1a1+
Tg(Prkcd-glc-1/CFP,-cre)EH124Gsat/0
Genetic
Background
involves: C57BL/6J * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-GFP,-RNAi:Eef1a1)Mcg mutation (0 available); any Col1a1 mutation (161 available)
Tg(Prkcd-glc-1/CFP,-cre)EH124Gsat mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice virally expressing a cre-dependent tet transactivator exhibit impaired conditioned safety response to withdrawal of cued stimuli compared with wild-type mice
• however, acquisition of differential threat associative memory is normal
• increased exploration of an elevated plus maze in mice virally expressing a cre-dependent tet transactivator





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/14/2024
MGI 6.23
The Jackson Laboratory