homeostasis/metabolism
N |
• mice fed a high-fat and high-sucrose diet exhibit normal respiratory exchange ratio
|
• in fasted and refed mice
|
• in fasted and refed mice
|
• in refed mice
• however, fasted mice exhibit normal levels
|
• in fasted and refed mice
• treatment with GSK2643943A does not alter cholesterol levels
• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype
|
• when mice are fed a high-fat and high-sucrose diet
|
• when mice are fed a high-fat and high-sucrose diet
|
• in fasted and refed mice
|
• in fasted and refed mice
• treatment with GSK2643943A does not alter triglyceride levels
• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype
|
• when mice are fed a high-fat and high-sucrose diet
|
• when mice are fed a high-fat and high-sucrose diet
|
• when mice are fed a high-fat and high-sucrose diet
• treatment with GSK2643943A does not ameliorate energy expenditure
• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype
|
• increased liver levels of HMG-CoA and succinate
• decreased liver levels of succinyl-CoA
|
• doubled serum succinate levels
|
• when mice are fed a high-fat and high-sucrose diet
|
• when mice are fed a high-fat and high-sucrose diet
• treatment with GSK2643943A does not alter glucose clearance
• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype
|
• when mice are fed a high-fat and high-sucrose diet
|
• in fasted and refed mice
|
• in fasted and refed mice
• decreased VLDL, LDL, and HDL
|
liver/biliary system
• reduced fat accumulation when mice are fed a high-fat and high-sucrose diet
|
• in fasted and refed mice
|
• in fasted and refed mice
• decreased VLDL, LDL, and HDL
|
• when mice are fed a high-fat and high-sucrose diet
|
growth/size/body
• when mice are fed a high-fat and high-sucrose diet
• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype
|
• when mice are fed a high-fat and high-sucrose diet
• however, lean body mass to body weight is normal
|
behavior/neurological
N |
• mice fed a high-fat and high-sucrose diet exhibit normal physical activity
|
adipose tissue
• when mice are fed a high-fat and high-sucrose diet
• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype
|
• reduced area
|
• when mice are fed a high-fat and high-sucrose diet
|