Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eportm1.1(EGFP/icre)Uk mutation
(2 available);
any
Epor mutation
(25 available)
Rasa3tm1.1Llp mutation
(0 available);
any
Rasa3 mutation
(62 available)
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hematopoietic system
N |
• although there is efficient deletion of exon 3 in red cell precursors, mice are normal at birth and at 6-8 weeks of age with normal spleen weights, normal blood morphology, and normal blood counts except for a clinically insignificant decrease in platelet number and slight increase in circulating reticulocytes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eportm1.1(EGFP/icre)Uk mutation
(2 available);
any
Epor mutation
(25 available)
Rasa3tm1.1Llp mutation
(0 available);
any
Rasa3 mutation
(62 available)
Rasa3tm1.3Llp mutation
(0 available);
any
Rasa3 mutation
(62 available)
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hematopoietic system
N |
• although there is efficient deletion of exon 3 in red cell precursors, mice are normal at birth and at 6-8 weeks of age with normal spleen weights, normal blood morphology, and normal blood counts except for a clinically insignificant decrease in platelet number and slight increase in circulating reticulocytes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1.1Llp mutation
(0 available);
any
Rasa3 mutation
(62 available)
Rasa3tm1.3Llp mutation
(0 available);
any
Rasa3 mutation
(62 available)
Tg(CMV-cre)1Cgn mutation
(6 available)
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mortality/aging
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• intercrosses of heterozygotes in the presence of a cre deleter yield no homozygous null animals at birth, showing the homozygous lethality of the null allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1.1Llp mutation
(0 available);
any
Rasa3 mutation
(62 available)
Tg(Vav1-cre)1Cgp mutation
(1 available)
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cardiovascular system
embryo
hematopoietic system
mortality/aging
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• all die in utero at E12.5 and E13.5 with severe hemorrhage and diminished fetal liver erythropoiesis
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1.1Llp mutation
(0 available);
any
Rasa3 mutation
(62 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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hematopoietic system
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• resulting from stress erythropoiesis after Poly(I:C) treatment
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• adults at 8-12 weeks of age were assessed after being injected with 300 ug Poly(I:C) every other day for 5 days and were found to have suppressed basal erythropoiesis with severe anemia, thrombocytopenia, and leukopenia, with very low CD45- erythroid and CD45+ non-erythroid cell counts in bone marrow, but progression between precursor stages is not affected, and stress erythropoiesis is found with markedly increased spleen size, increased red pulp, increased BFU-E and CFU-E, increased erythroblasts, and reticulocytosis
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• profound anemia after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• in spleen after Poly(I:C) treatment
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• indicated by increased LDH and bilirubin after Poly(I:C) treatment
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• after Poly(I:C) treatment
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homeostasis/metabolism
immune system
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• resulting from stress erythropoiesis after Poly(I:C) treatment
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• after Poly(I:C) treatment
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• after Poly(I:C) treatment
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growth/size/body
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• resulting from stress erythropoiesis after Poly(I:C) treatment
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1.1Llp mutation
(0 available);
any
Rasa3 mutation
(62 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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cardiovascular system
mortality/aging
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• all die in utero at E12.5 and E13.5 with severe hemorrhage and diminished fetal liver erythropoiesis
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embryo
hematopoietic system