Phenotypes associated with this allele

• Allele Symbol: Igs2^{tm1(CAG-Met)Zsu}
• Allele Name: targeted mutation 1, Zijie Sun
• Allele ID: MGI:6507851
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Igs2^tm1(CAG-Met)Zsu/Igs2^+ Pten^tm1Hwu/Pten^tm1Hwu Tg(Pbsn-cre)4Prb/0	involves: 129 * C57BL/6 * DBA/2 * FVB/N	MGI:6507866
cn2	Igs2^tm1(CAG-Met)Zsu/Igs2^+ Tg(Pbsn-cre)4Prb/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * FVB/N	MGI:6507865
cn3	Ctnnb1^tm1Mmt/Ctnnb1^+ Igs2^tm1(CAG-Met)Zsu/Igs2^+ Tg(Pbsn-cre)4Prb/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * FVB/N	MGI:6507888

Genotype
MGI:6507866

cn1

• Allelic Composition: Igs2^{tm1(CAG-Met)Zsu}/Igs2⁺; Pten^tm1Hwu/Pten^tm1Hwu; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129 * C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:268934 )

♂ • mice develop prostatic sarcomatoid carcinoma

♂ • mice show a more aggressive prostatic tumor phenotype than single conditional Pten^tm1Hwu mice

increased prostate gland adenocarcinoma incidence ( J:268934 )

♂ • mice develop prostatic adenocarcinomas and invasive carcinomas

increased prostate intraepithelial neoplasia incidence ( J:268934 )

♂ • 5 of 5 mice develop multifocal high grade intraepithelial neoplasia (PIN) before 4 months of age

neoplasm

increased prostate gland tumor incidence ( J:268934 )

♂ • mice develop prostatic sarcomatoid carcinoma

♂ • mice show a more aggressive prostatic tumor phenotype than single conditional Pten^tm1Hwu mice

increased prostate gland adenocarcinoma incidence ( J:268934 )

♂ • mice develop prostatic adenocarcinomas and invasive carcinomas

increased prostate intraepithelial neoplasia incidence ( J:268934 )

♂ • 5 of 5 mice develop multifocal high grade intraepithelial neoplasia (PIN) before 4 months of age

increased metastatic potential ( J:268934 )

♂ • prostate cancer metastasis after 10 months of age with 62.5% of mice showing metastatic lesions

♂ • metastasis to lungs and periprostatic lymph nodes is seen

♂ • mice show an overall more invasive tumor phenotype than single conditional Pten^tm1Hwu mice

increased carcinoma incidence ( J:268934 )

♂ • 1 of 5 mice show invasive pancreatic carcinoma at 4-10 months and 6 of 8 mice develop invasive carcinoma after 10 months of age; 5 of 8 mice have invasive carcinoma with epithelial-mesenchymal transition and 5 of 8 mice have invasive carcinoma with metastasis

♂ • mice exhibit a transition from prostatic adenocarcinoma and invasive carcinoma lesions to pathology resembling prostatic sarcamoid carcinomas

♂ • sarcamoid carcinomas show spindle-like tumor cells, tumor cells with a multitude of mitotic figures, and haphazard acini and lobules of pleomorphic cells, indicating that these lesions possess mesenchymal morphology and proliferative and invasive features

reproductive system

increased prostate gland tumor incidence ( J:268934 )

♂ • mice develop prostatic sarcomatoid carcinoma

♂ • mice show a more aggressive prostatic tumor phenotype than single conditional Pten^tm1Hwu mice

increased prostate gland adenocarcinoma incidence ( J:268934 )

♂ • mice develop prostatic adenocarcinomas and invasive carcinomas

increased prostate intraepithelial neoplasia incidence ( J:268934 )

♂ • 5 of 5 mice develop multifocal high grade intraepithelial neoplasia (PIN) before 4 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:268934

Genotype
MGI:6507865

cn2

• Allelic Composition: Igs2^{tm1(CAG-Met)Zsu}/Igs2⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * FVB/N

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:268934 )

N • mice do not show any obvious pathological changes in prostate tissues from birth to 20 months of age

increased prostate intraepithelial neoplasia incidence ( J:268934 )

• mice administered recombinant human hepatocyte growth factor at 6 months of age show lesions of typical low-grade prostatic intraepithelial neoplasia not seen in hepatocyte growth factor-administered wild-type mice

• however, hepatocyte growth factor-administered mice do not develop prostate carcinomas

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:268934 )

• mice administered recombinant human hepatocyte growth factor at 6 months of age show lesions of typical low-grade prostatic intraepithelial neoplasia not seen in hepatocyte growth factor-administered wild-type mice

• however, hepatocyte growth factor-administered mice do not develop prostate carcinomas

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:268934 )

• mice administered recombinant human hepatocyte growth factor at 6 months of age show lesions of typical low-grade prostatic intraepithelial neoplasia not seen in hepatocyte growth factor-administered wild-type mice

• however, hepatocyte growth factor-administered mice do not develop prostate carcinomas

Genotype
MGI:6507888

cn3

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Igs2^{tm1(CAG-Met)Zsu}/Igs2⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * FVB/N

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:284956 )

♂ • mice develop aggressive adenocarcinomas that occur with much higher frequency than in single Ctnnb1^tm1Mmt conditional mutants, developing prostatic invasive adenocarcinomas as early as 7 months of age

♂ • 4 of 4 mice show intracystic adenocarcinoma at 6-9 months of age, with 1 of 4 mice showing invasive adenocarcinoma

♂ • 13 of 13 mice show intracystic adenocarcinoma at 9 months or older, with 5 of 13 showing invasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:284956 )

♂ • mice develop PIN lesions starting at 4-6 weeks of age, with 5 of 5 mice showing high grade PIN before 6 months of age

♂ • mice develop more severe PIN lesions and faster disease progression than single Ctnnb1^tm1Mmt conditional mutants

♂ • lesions in the anterior, dorsal, and lateral prostate lobes are more severe than in the ventral prostate

♂ • typical cribriform and papilliferous structures completely fill the lumen of prostatic glands

neoplasm

increased prostate gland adenocarcinoma incidence ( J:284956 )

♂ • mice develop aggressive adenocarcinomas that occur with much higher frequency than in single Ctnnb1^tm1Mmt conditional mutants, developing prostatic invasive adenocarcinomas as early as 7 months of age

♂ • 4 of 4 mice show intracystic adenocarcinoma at 6-9 months of age, with 1 of 4 mice showing invasive adenocarcinoma

♂ • 13 of 13 mice show intracystic adenocarcinoma at 9 months or older, with 5 of 13 showing invasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:284956 )

♂ • mice develop PIN lesions starting at 4-6 weeks of age, with 5 of 5 mice showing high grade PIN before 6 months of age

♂ • mice develop more severe PIN lesions and faster disease progression than single Ctnnb1^tm1Mmt conditional mutants

♂ • lesions in the anterior, dorsal, and lateral prostate lobes are more severe than in the ventral prostate

♂ • typical cribriform and papilliferous structures completely fill the lumen of prostatic glands

reproductive system

increased prostate gland adenocarcinoma incidence ( J:284956 )

♂ • mice develop aggressive adenocarcinomas that occur with much higher frequency than in single Ctnnb1^tm1Mmt conditional mutants, developing prostatic invasive adenocarcinomas as early as 7 months of age

♂ • 4 of 4 mice show intracystic adenocarcinoma at 6-9 months of age, with 1 of 4 mice showing invasive adenocarcinoma

♂ • 13 of 13 mice show intracystic adenocarcinoma at 9 months or older, with 5 of 13 showing invasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:284956 )

♂ • mice develop PIN lesions starting at 4-6 weeks of age, with 5 of 5 mice showing high grade PIN before 6 months of age

♂ • mice develop more severe PIN lesions and faster disease progression than single Ctnnb1^tm1Mmt conditional mutants

♂ • lesions in the anterior, dorsal, and lateral prostate lobes are more severe than in the ventral prostate

♂ • typical cribriform and papilliferous structures completely fill the lumen of prostatic glands

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:284956