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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map9tm1.2Bcgen
targeted mutation 1.2, Biocytogen LLC
MGI:6502642
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map9tm1.2Bcgen/Map9tm1.2Bcgen involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 MGI:6502657
ht2
 		Map9tm1.2Bcgen/Map9+ involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 MGI:6502658
cx3
 		Map9tm1.2Bcgen/Map9tm1.2Bcgen
Trp53tm1Tyj/Trp53+ 		involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6 MGI:6502662
cx4
 		ApcMin/Apc+
Map9tm1.2Bcgen/Map9tm1.2Bcgen 		involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6J MGI:6502660
cx5
 		ApcMin/Apc+
Map9tm1.2Bcgen/Map9+ 		involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6J MGI:6502661


Genotype
MGI:6502657
hm1
Allelic
Composition		 Map9tm1.2Bcgen/Map9tm1.2Bcgen
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal centrosome morphology ( J:299895 )
• MEFs show an increase in the percentage of cells with detached centrosomes compared with wild-type MEFs
abnormal pericentriolar material morphology ( J:299895 )
• MEFs show an increase in pericentriolar material fragmentation compared with wild-type MEFs
aneuploidy ( J:299895 )
• 70-80% of mouse embryonic fibroblasts (MEFs) are aneuploid
• -the percentage of MEFs with numerical aberrations is almost 3x higher than that of wild-type MEFs
chromosomal instability ( J:299895 )
• MEFs show elevated rates of lagging chromosomes in anaphase indicating increased chromosomal instability

neoplasm
neoplasm ( J:299895 )
N
• mice do not develop visible tumors at 3 months of age




Genotype
MGI:6502658
ht2
Allelic
Composition		 Map9tm1.2Bcgen/Map9+
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal centrosome morphology ( J:299895 )
• MEFs show an increase in the percentage of cells with detached centrosomes compared with wild-type MEFs
abnormal pericentriolar material morphology ( J:299895 )
• MEFs show an increase in pericentriolar material fragmentation compared with wild-type MEFs
aneuploidy ( J:299895 )
• a large percentage of mouse embryonic fibroblasts (MEFs) are aneuploid
chromosomal instability ( J:299895 )
• MEFs show elevated rates of lagging chromosomes in anaphase indicating increased chromosomal instability




Genotype
MGI:6502662
cx3
Allelic
Composition		 Map9tm1.2Bcgen/Map9tm1.2Bcgen
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (26 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
aneuploidy ( J:299895 )
• aneuploidy frequency in splenocytes is higher (58%) compared to single Map9 heterozygotes (39%) or single p53 heterozygotes (23%) or wild-type mice (17%)




Genotype
MGI:6502660
cx4
Allelic
Composition		 ApcMin/Apc+
Map9tm1.2Bcgen/Map9tm1.2Bcgen
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

neoplasm
increased colon tumor incidence ( J:299895 )
• nearly all mice develop intestinal tumors at 3 months of age, with 5 of 8 mice showing multiple tumors
• mice have 3-fold more tumors that heterozygous ApcMin heterozygotes, accompanied by significant weight loss
• average tumor burden (sum of all tumor size per mouse) is 2x greater than in ApcMin heterozygotes
• colon tumors harbor chromosomal abnormalities, with tumors having more somatic structural variations, interchromosomal translocations, and intrachromosomal translocations

digestive/alimentary system
increased colon tumor incidence ( J:299895 )
• nearly all mice develop intestinal tumors at 3 months of age, with 5 of 8 mice showing multiple tumors
• mice have 3-fold more tumors that heterozygous ApcMin heterozygotes, accompanied by significant weight loss
• average tumor burden (sum of all tumor size per mouse) is 2x greater than in ApcMin heterozygotes
• colon tumors harbor chromosomal abnormalities, with tumors having more somatic structural variations, interchromosomal translocations, and intrachromosomal translocations




Genotype
MGI:6502661
cx5
Allelic
Composition		 ApcMin/Apc+
Map9tm1.2Bcgen/Map9+
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased colon tumor incidence ( J:299895 )
• nearly all mice develop intestinal tumors at 3 months of age, with 2 of 10 mice showing multiple tumors

digestive/alimentary system
increased colon tumor incidence ( J:299895 )
• nearly all mice develop intestinal tumors at 3 months of age, with 2 of 10 mice showing multiple tumors




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory