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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ythdf2em2Jhha
endonuclease-mediated mutation 2, Jacob Hanna
MGI:6491617
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ythdf2em2Jhha/Ythdf2em2Jhha involves: BALB/c * C57BL/6 MGI:6491912
cx2
 		Ythdf1em2Jhha/Ythdf1em2Jhha
Ythdf2em2Jhha/Ythdf2em2Jhha
Ythdf3em2Jhha/Ythdf3em2Jhha 		involves: BALB/c * C57BL/6 MGI:6491914
cx3
 		Ythdf1em2Jhha/Ythdf1em2Jhha
Ythdf2em2Jhha/Ythdf2+
Ythdf3em2Jhha/Ythdf3em2Jhha 		involves: BALB/c * C57BL/6 MGI:6491915
cx4
 		Ythdf1em2Jhha/Ythdf1em2Jhha
Ythdf2em2Jhha/Ythdf2+
Ythdf3em2Jhha/Ythdf3+ 		involves: BALB/c * C57BL/6 MGI:6491916
cx5
 		Ythdf1em2Jhha/Ythdf1+
Ythdf2em2Jhha/Ythdf2+
Ythdf3em2Jhha/Ythdf3em2Jhha 		involves: BALB/c * C57BL/6 MGI:6491917


Genotype
MGI:6491912
hm1
Allelic
Composition		 Ythdf2em2Jhha/Ythdf2em2Jhha
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdf2em2Jhha mutation (0 available); any Ythdf2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
oligozoospermia ( J:299108 )
• severe loss of sperm in cauda epididymis

endocrine/exocrine glands
abnormal Sertoli cell morphology ( J:299108 )
• large, scattered vacuoles
seminiferous tubule degeneration ( J:299108 )
• mild degeneration

mortality/aging
preweaning lethality, incomplete penetrance ( J:299108 )
• 80% of newborns die shortly after birth

reproductive system
reproductive system phenotype ( J:299108 )
N
• normal oocyte morphology; oocytes can be fertilized
oligozoospermia ( J:299108 )
• severe loss of sperm in cauda epididymis
abnormal Sertoli cell morphology ( J:299108 )
• large, scattered vacuoles
seminiferous tubule degeneration ( J:299108 )
• mild degeneration
female infertility ( J:299108 )
• oocytes can be fertilized but do not develop beyond 8-cell stage
reduced male fertility ( J:299108 )
• severe loss of sperm in cauda epididymis




Genotype
MGI:6491914
cx2
Allelic
Composition		 Ythdf1em2Jhha/Ythdf1em2Jhha
Ythdf2em2Jhha/Ythdf2em2Jhha
Ythdf3em2Jhha/Ythdf3em2Jhha
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdf1em2Jhha mutation (0 available); any Ythdf1 mutation (36 available)
Ythdf2em2Jhha mutation (0 available); any Ythdf2 mutation (30 available)
Ythdf3em2Jhha mutation (0 available); any Ythdf3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6491915
cx3
Allelic
Composition		 Ythdf1em2Jhha/Ythdf1em2Jhha
Ythdf2em2Jhha/Ythdf2+
Ythdf3em2Jhha/Ythdf3em2Jhha
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdf1em2Jhha mutation (0 available); any Ythdf1 mutation (36 available)
Ythdf2em2Jhha mutation (0 available); any Ythdf2 mutation (30 available)
Ythdf3em2Jhha mutation (0 available); any Ythdf3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6491916
cx4
Allelic
Composition		 Ythdf1em2Jhha/Ythdf1em2Jhha
Ythdf2em2Jhha/Ythdf2+
Ythdf3em2Jhha/Ythdf3+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdf1em2Jhha mutation (0 available); any Ythdf1 mutation (36 available)
Ythdf2em2Jhha mutation (0 available); any Ythdf2 mutation (30 available)
Ythdf3em2Jhha mutation (0 available); any Ythdf3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:299108 )
• mice born at lower than expected Mendelian ratio




Genotype
MGI:6491917
cx5
Allelic
Composition		 Ythdf1em2Jhha/Ythdf1+
Ythdf2em2Jhha/Ythdf2+
Ythdf3em2Jhha/Ythdf3em2Jhha
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdf1em2Jhha mutation (0 available); any Ythdf1 mutation (36 available)
Ythdf2em2Jhha mutation (0 available); any Ythdf2 mutation (30 available)
Ythdf3em2Jhha mutation (0 available); any Ythdf3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:299108 )
• mice born at lower than expected Mendelian ratio




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory