All Phenotypes Trp53<tm2.1Thst> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm2.1Thst
targeted mutation 2.1, Thorsten Stiewe
MGI:6479078

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm2.1Thst/Trp53^tm2.1Thst	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:6479119
ht2	Trp53^tm2.1Thst/Trp53⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:6479116
ht3	Trp53^tm2Thst/Trp53^tm2.1Thst	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:6479115
cx4	Trp53^tm2.1Thst/Trp53⁺ Tg(IghMyc)22Bri/0	involves: 129 * C57BL * SJL	MGI:6479118

Allelic Composition	Trp53^tm2.1Thst/Trp53^tm2.1Thst
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm2.1Thst mutation (1 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:282255 )

• mice develop tumors resulting in reduced survival (150 days)

neoplasm

abnormal tumor incidence ( J:282255 )

• mice develop tumors resulting in reduced survival (150 days)

• however, tumor metastatic potential is normal

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

increased testis tumor incidence ( J:282255 )

• in some mice

increased B cell derived lymphoma incidence ( J:282255 )

• in some mice

increased carcinoma incidence ( J:282255 )

• in some mice

increased sarcoma incidence ( J:282255 )

• in some mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

increased testis tumor incidence ( J:282255 )

• in some mice

reproductive system

increased testis tumor incidence ( J:282255 )

• in some mice

immune system

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

hematopoietic system

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

Allelic Composition	Trp53^tm2.1Thst/Trp53⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm2.1Thst mutation (1 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:282255 )

• median survival is 519 days

Allelic Composition	Trp53^tm2Thst/Trp53^tm2.1Thst
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm2.1Thst mutation (1 available); any Trp53 mutation (238 available)
Trp53^tm2Thst mutation (1 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:282255 )

• mice develop tumors resulting in reduced survival (128 days)

neoplasm

abnormal tumor incidence ( J:282255 )

• mice develop tumors resulting in reduced survival (128 days)

• however, tumor metastatic potential is normal

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

increased testis tumor incidence ( J:282255 )

• in some mice

increased B cell derived lymphoma incidence ( J:282255 )

• in some mice

increased carcinoma incidence ( J:282255 )

• in some mice

increased sarcoma incidence ( J:282255 )

• in some mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

increased testis tumor incidence ( J:282255 )

• in some mice

reproductive system

increased testis tumor incidence ( J:282255 )

• in some mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

immune system

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

Allelic Composition	Trp53^tm2.1Thst/Trp53⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: 129 * C57BL * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (2 available)
Trp53^tm2.1Thst mutation (1 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:282255 )

• similar to mice with a null Trp53 allele, mice exhibit shorter survival than those with wild-type Trp53

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24