Phenotypes associated with this allele

• Allele Symbol: Dcp2^tm1Smoc
• Allele Name: targeted mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6459897
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dcp2^tm1Smoc/Dcp2^tm1Smoc Ndor1^Tg(UBC-cre/ERT2)1Ejb/Ndor1^+	involves: 129S/SvEv * C57BL/6	MGI:6459915

Genotype
MGI:6459915

cn1

• Allelic Composition: Dcp2^tm1Smoc/Dcp2^tm1Smoc; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased male germ cell number ( J:292283 )

♂ • progressive loss with only a few elongated spermatids in tamoxifen-treated mice

increased male germ cell apoptosis ( J:292283 )

♂ • in tamoxifen-treated mice

asthenozoospermia ( J:292283 )

♂ • in tamoxifen-treated mice

decreased testis weight ( J:292283 )

♂ • in tamoxifen-treated mice

male infertility ( J:292283 )

♂ • in tamoxifen-treated mice

homeostasis/metabolism

decreased circulating testosterone level ( J:292283 )

♂ • in tamoxifen-treated mice

increased circulating follicle stimulating hormone level ( J:292283 )

♂ • in tamoxifen-treated mice

increased circulating luteinizing hormone level ( J:292283 )

♂ • in tamoxifen-treated mice

cellular

decreased male germ cell number ( J:292283 )

♂ • progressive loss with only a few elongated spermatids in tamoxifen-treated mice

increased male germ cell apoptosis ( J:292283 )

♂ • in tamoxifen-treated mice

asthenozoospermia ( J:292283 )

♂ • in tamoxifen-treated mice

endocrine/exocrine glands

decreased testis weight ( J:292283 )

♂ • in tamoxifen-treated mice