Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdia6m1Btlr mutation
(0 available);
any
Pdia6 mutation
(30 available)
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growth/size/body
immune system
N |
• reduced T cell-independent (TI) antibody responses to NP-Ficoll
• moderate reduction in T cell-dependent antibody responses to aluminum hydroxide-precipitated ovalbumin
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdia6em1Btlr mutation
(0 available);
any
Pdia6 mutation
(30 available)
Pdia6m1Btlr mutation
(0 available);
any
Pdia6 mutation
(30 available)
|
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immune system
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• age-dependent and progressive after 6 weeks of age
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• increased mature recirculating B cells
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• age-dependent and progressive after 6 weeks of age
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• age-dependent and progressive after 6 weeks of age
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• in total numbers (with a decrease in frequency)
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• in total numbers (with a increase in frequency)
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• decreased total B cells
• however, the number of B1-cells in the peritoneal is normal
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• reduced frequency of natural killer and NK1.1+ T cells
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• age-dependent and progressive after 6 weeks of age
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• age-dependent and progressive after 6 weeks of age
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• reduced T cell-independent (TI) antibody responses to NP-Ficoll
• moderate reduction in T cell-dependent antibody responses to aluminum hydroxide-precipitated ovalbumin
|
growth/size/body
homeostasis/metabolism
endocrine/exocrine glands
N |
• mice exhibit normal islet architecture
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• age-dependent and progressive after 6 weeks of age
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hematopoietic system
N |
• mice exhibit normal neutrophil numbers
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• age-dependent and progressive after 6 weeks of age
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• decreased CD11c+ or CD11b+ myeloid cells
• age-dependent and progressive after 6 weeks of age
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• increased mature recirculating B cells
|
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• age-dependent and progressive after 6 weeks of age
|
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• age-dependent and progressive after 6 weeks of age
|
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• in total numbers (with a decrease in frequency)
|
|
• in total numbers (with a increase in frequency)
|
|
• decreased total B cells
• however, the number of B1-cells in the peritoneal is normal
|
|
• reduced frequency of natural killer and NK1.1+ T cells
|
|
• age-dependent and progressive after 6 weeks of age
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• decreased proportion of LSK+ cells with increase in long-term and short-term hematopoietic stem cells
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• age-dependent and progressive after 6 weeks of age
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• reduced T cell-independent (TI) antibody responses to NP-Ficoll
• moderate reduction in T cell-dependent antibody responses to aluminum hydroxide-precipitated ovalbumin
|