Phenotypes associated with this allele

• Allele Symbol: Prr19^em1Atot
• Allele Name: endonuclease-mediated mutation 1, Attila Toth
• Allele ID: MGI:6455144
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prr19^em1Atot/Prr19^em1Atot	either: (involves: C57BL/6JCrl) or (involves: CD-1)	MGI:6455163

Genotype
MGI:6455163

hm1

• Allelic Composition: Prr19^em1Atot/Prr19^em1Atot
• Genetic Background: either: (involves: C57BL/6JCrl) or (involves: CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased oocyte number ( J:292293 )

♀

oligozoospermia ( J:292293 )

♂

teratozoospermia ( J:292293 )

♂ • large round spermatid-like cells in seminiferous tubules

increased male germ cell apoptosis ( J:292293 )

♂ • peaking in late pachytene

decreased testis weight ( J:292293 )

♂

abnormal meiosis ( J:292293 )

• mice fail in crossover differentiation unlike wild-type mice

abnormal X-Y chromosome synapsis during male meiosis ( J:292293 )

♂

female infertility ( J:292293 )

♀

male infertility ( J:292293 )

♂

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:292293 )

• delayed repair in spermatocytes and oocytes

endocrine/exocrine glands

decreased testis weight ( J:292293 )

♂

cellular

decreased oocyte number ( J:292293 )

♀

oligozoospermia ( J:292293 )

♂

teratozoospermia ( J:292293 )

♂ • large round spermatid-like cells in seminiferous tubules

increased male germ cell apoptosis ( J:292293 )

♂ • peaking in late pachytene

abnormal double-strand DNA break repair ( J:292293 )

• delayed repair in spermatocytes and oocytes