Analysis Tools
mortality/aging
|
• pups only survive a few hours after birth with signs of severe hypoxia
|
cardiovascular system
| N |
• mice exhibit normal blood brain barrier function
|
|
• in the median and lateral ganglionic eminences at E15.5
• progressive hypoplastic periventricular vessels from E14.5 to E18.5
• reduced area of the brain periventricular parenchyma covered by vessels and dilated vascular tubes with clumping of endothelial nuclei within vessel walls
• however, periventricular vessels are normal at E12.5
|
|
• dilated vascular tubes with clumping of endothelial nuclei within vessel walls
|
|
• slightly reduced pericyte coverage in the brain at E18.5
• however, coverage is normal at E12.5 and E14.5
|
|
• stalled periventricular blood vessels ingression toward the ventricular zone forming a vascular plexus
|
|
• in the brain
• endothelial cells exhibit reduced and length of filopodia at E 12.5 and E14.5 at vascular fronts compared with control cells
|
nervous system
|
• in the median and lateral ganglionic eminences at E15.5
• progressive hypoplastic periventricular vessels from E14.5 to E18.5
• reduced area of the brain periventricular parenchyma covered by vessels and dilated vascular tubes with clumping of endothelial nuclei within vessel walls
• however, periventricular vessels are normal at E12.5
|
|
• dilated vascular tubes with clumping of endothelial nuclei within vessel walls
|
|
• accumulation of myeloid cells in the brain at E18 secondary to alterations
|
|
• at E18.5
|
|
• with massive cell death in the ventral parts of the brain at E18.5
• however, few apoptotic endothelial cells in the brain
|
homeostasis/metabolism
behavior/neurological
bradykinesia
(
J:287134
)
|
• at birth
|
cellular
|
• at E14.5 in the ganglionic eminences
• however, proliferation at E12.5 is normal
|
immune system
|
• accumulation of myeloid cells in the brain at E18 secondary to alterations
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome | DOID:0111666 |
OMIM:225790 |
J:287134 | |
