About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm1(CAG-BRF1)Gu
targeted mutation 1, University of Glasgow
MGI:6403376
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0 		involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * FVB/N MGI:6403693
cn2
 		Brf1tm1Arte/Brf1tm1Arte
Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Tg(Cyp1a1-cre)1Dwi/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:6403686


Genotype
MGI:6403693
cn1
Allelic
Composition		 Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CAG-BRF1)Gu mutation (0 available); any Hprt1 mutation (1279 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm2Tyj mutation (2 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:285667 )
• as in mice lacking the BRF1 knock-in

neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• as in mice lacking the BRF1 knock-in

homeostasis/metabolism
abnormal translation ( J:285667 )
• tRNA levels are increased in the pancreas

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• as in mice lacking the BRF1 knock-in

cellular
abnormal translation ( J:285667 )
• tRNA levels are increased in the pancreas




Genotype
MGI:6403686
cn2
Allelic
Composition		 Brf1tm1Arte/Brf1tm1Arte
Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brf1tm1Arte mutation (0 available); any Brf1 mutation (24 available)
Hprt1tm1(CAG-BRF1)Gu mutation (0 available); any Hprt1 mutation (1279 available)
Tg(Cyp1a1-cre)1Dwi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:285667 )
N
• mice exhibit normal circulating liver enzyme, liver size, and liver cell proliferation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory