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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Brf1tm1Arte
targeted mutation 1, TaconicArtemis
MGI:6403351
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Brf1tm1Arte/Brf1tm1Arte Not Specified MGI:6403684
cn2
 		Brf1tm1Arte/Brf1tm1Arte
Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Tg(Cyp1a1-cre)1Dwi/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:6403686
cn3
 		Brf1tm1Arte/Brf1tm1Arte
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * 129S7/SvEvBrd * FVB/N MGI:6403690
cn4
 		Brf1tm1Arte/Brf1tm1Arte
Tg(Cyp1a1-cre)1Dwi/0 		involves: C57BL/6 * CBA MGI:6403685
cn5
 		Apctm1Tno/Apc+
Brf1tm1Arte/Brf1tm1Arte
Tg(Cyp1a1-cre)1Dwi/0 		involves: C57BL/6 * CBA MGI:6403689
cn6
 		Brf1tm1Arte/Brf1tm1Arte
Tg(Pdx1-cre)6Tuv/0 		involves: FVB/N MGI:6403691


Genotype
MGI:6403684
cn1
Allelic
Composition		 Brf1tm1Arte/Brf1tm1Arte
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brf1tm1Arte mutation (0 available); any Brf1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating bilirubin level ( J:285667 )
• in mice treated with a cre-expressing adenovirus
increased circulating alanine transaminase level ( J:285667 )
• in mice treated with a cre-expressing adenovirus
increased circulating alkaline phosphatase level ( J:285667 )
• in mice treated with a cre-expressing adenovirus

growth/size/body
decreased body weight ( J:285667 )
• in mice treated with a cre-expressing adenovirus




Genotype
MGI:6403686
cn2
Allelic
Composition		 Brf1tm1Arte/Brf1tm1Arte
Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brf1tm1Arte mutation (0 available); any Brf1 mutation (23 available)
Hprt1tm1(CAG-BRF1)Gu mutation (0 available); any Hprt1 mutation (1274 available)
Tg(Cyp1a1-cre)1Dwi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:285667 )
N
• mice exhibit normal circulating liver enzyme, liver size, and liver cell proliferation




Genotype
MGI:6403690
cn3
Allelic
Composition		 Brf1tm1Arte/Brf1tm1Arte
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brf1tm1Arte mutation (0 available); any Brf1 mutation (23 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm2Tyj mutation (4 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:285667 )
• extended survival compared to control mice with normal Brf1

neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• at a reduced rate and with extended survival compared to control mice with normal Brf1
• however, tumors that do form lack recombined Brf1

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• at a reduced rate and with extended survival compared to control mice with normal Brf1
• however, tumors that do form lack recombined Brf1




Genotype
MGI:6403685
cn4
Allelic
Composition		 Brf1tm1Arte/Brf1tm1Arte
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brf1tm1Arte mutation (0 available); any Brf1 mutation (23 available)
Tg(Cyp1a1-cre)1Dwi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
small liver ( J:285667 )
• at P8

homeostasis/metabolism
abnormal translation ( J:285667 )
• reduce in polysome loading at P4 in the liver due to shortage of tRNA
• absent polysome at P8

immune system

cellular
abnormal translation ( J:285667 )
• reduce in polysome loading at P4 in the liver due to shortage of tRNA
• absent polysome at P8




Genotype
MGI:6403689
cn5
Allelic
Composition		 Apctm1Tno/Apc+
Brf1tm1Arte/Brf1tm1Arte
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation (6 available); any Apc mutation (154 available)
Brf1tm1Arte mutation (0 available); any Brf1 mutation (23 available)
Tg(Cyp1a1-cre)1Dwi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• mice develop similar tumor number and size as in Apctm1aTno Tg(Cyp1a1-cre)1Dwi heterozygotes

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• mice develop similar tumor number and size as in Apctm1aTno Tg(Cyp1a1-cre)1Dwi heterozygotes




Genotype
MGI:6403691
cn6
Allelic
Composition		 Brf1tm1Arte/Brf1tm1Arte
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brf1tm1Arte mutation (0 available); any Brf1 mutation (23 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:285667 )
N
• normal pancreata




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory