Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(DPP4)2Nnag mutation
(0 available)
Tmprss2tm1(KOMP)Vlcg mutation
(0 available);
any
Tmprss2 mutation
(46 available)
|
|
|
immune system
|
|
• MERS-CoV-infected mice show a delay in and less pronounced chemokine and cytokine responses, with decreased concentrations of FGF-basic, GM-CSF, MIG/CXCL9, and TNF-alpha but increased levels of IL-6 and other inflammatory cytokines like MIP-1alpha, IL-1alpha and IL-1beta
|
|
|
• mice show decreased susceptibility to infection with the EMC2012 strain of the Middle East respiratory syndrome coronavirus (MERS-CoV) , with no or only a slight weight loss, slower viral replication in the lungs, lower titers of neutralizing antibodies in sera, and less severe lung pathology with only mild mononuclear cell infiltration of the alveoli by 7 days post infection compared to single Tg(DPP4)2Nnag mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
immune system
|
|
• MERS-CoV-infected mice (both young and adults) show increased expression of proinflammatory cytokines and chemokines in the lungs, including IP-10, IL-6, IL-13, MCP-1, MIP-1alpha, MIG, IL-12, and IFN-gamma, with higher levels of IP-10, IL-12, and IL-1beta in adult mice and IL-1alpha and IL-17 detected only in the adult mice, and a transient increase in IFN-alpha4 and IFN-beta in adults, indicating a more severe reaction in aged mice
|
|
|
• 10 week old mice infected with MERS-CoV show progressive pulmonary inflammation and develop acute pneumonia from which they recover; inflammatory reactions include partial and/or mild perivascular and peribronchiolar infiltration by mononuclear cells and eosinophils in alveolar areas on 3 and 5 dpi, and severe lung inflammation, including perivascular and alveolar septal thickening causing by infiltrating mononuclear cells on 7 dpi, clearing of inflammatory responses is seen by 35 dpi although focal cellular infiltration is still seen in the peribronchioles and alveolar septa and no inflammation is seen in the brain through 35 dpi
• 25 week old mice infected with MERS-CoV show delayed and prolonged inflammatory responses in the lung compared to 10 week old mice
|
|
|
• 10 week old (young) mice are permissive to intranasal infection with the EMC 2012 strain of Middle East respiratory syndrome coronavirus (MERS-CoV) , showing a mild but transient weight loss from days 6 to 7 postinoculation (dpi), seroconversion at 35 dpi, virus titers detectable up to 5 dpi in the lungs and eliminated by 7 dpi, and very low copy numbers of viral RNA in the blood at 3 and 5 dpi, indicating that the virus infects and replicates mainly in the lower respiratory tract and is eliminated within 7 days of infection
• 25 week old (adult) mice infected with MERS-CoV show weight loss but recover by 14 dpi, show no obvious signs such as respiratory illness and mortality but show delayed and prolonged inflammatory responses in the lung compared to 10 week old mice
• however, mice infected with MERS-CoV do not show viral RNA in the brain or spleen
|
homeostasis/metabolism
respiratory system
|
|
• 10 week old mice infected with MERS-CoV show progressive pulmonary inflammation and develop acute pneumonia from which they recover; inflammatory reactions include partial and/or mild perivascular and peribronchiolar infiltration by mononuclear cells and eosinophils in alveolar areas on 3 and 5 dpi, and severe lung inflammation, including perivascular and alveolar septal thickening causing by infiltrating mononuclear cells on 7 dpi, clearing of inflammatory responses is seen by 35 dpi although focal cellular infiltration is still seen in the peribronchioles and alveolar septa and no inflammation is seen in the brain through 35 dpi
• 25 week old mice infected with MERS-CoV show delayed and prolonged inflammatory responses in the lung compared to 10 week old mice
|
Analysis Tools