All Phenotypes Chp1<em1(IMPC)Tcp> MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:374598 )

• homozygous embryos are present in near Mendelian ratios at E7.5 and E8.5 but underrepresented at E9.5 and absent at E12.5

abnormal head shape ( J:374598 )

• by E9.5, nearly all homozygous embryos have a profoundly abnormal head shape

embryonic growth retardation ( J:374598 )

• nearly all homozygous embryos are developmentally delayed at E8.5; all are delayed by E9.5

• at E8.5, delayed embryos exhibit POU5F1/OCT4 staining in the remnant of the primitive streak and nascent mesodermal layer and absence of CDH2/NCAD staining in mesodermal derivatives including the developing cardiac tissue and allantois, unlike E8.5 control littermates

• however, by E9.5, all homozygous embryos show normal neural tube patterning and presence of a gut tube and a heart tube, indicating that all three germ layers are present

decreased embryo size ( J:374598 )

• at E7.5, homozygous embryos are always the smallest in the litter

• by E9.5, all homozygous embryos are smaller than control littermates

incomplete embryo turning ( J:374598 )

• by E9.5, none of the homozygous embryos have turned appropriately

embryonic growth retardation ( J:374598 )

• nearly all homozygous embryos are developmentally delayed at E8.5; all are delayed by E9.5

• at E8.5, delayed embryos exhibit POU5F1/OCT4 staining in the remnant of the primitive streak and nascent mesodermal layer and absence of CDH2/NCAD staining in mesodermal derivatives including the developing cardiac tissue and allantois, unlike E8.5 control littermates

• however, by E9.5, all homozygous embryos show normal neural tube patterning and presence of a gut tube and a heart tube, indicating that all three germ layers are present

abnormal embryo morphology ( J:374598 )

• by E9.5, all homozygous embryos are severely dysmorphic and smaller than controls

decreased embryo size ( J:374598 )

• at E7.5, homozygous embryos are always the smallest in the litter

• by E9.5, all homozygous embryos are smaller than control littermates

incomplete rostral neuropore closure ( J:374598 )

• by E9.5, most homozygous embryos have failed to close the cranial neural tube

abnormal allantois morphology ( J:374598 )

• at E8.5, most homozygous embryos display an irregularly shaped allantois that is blebby at the tip

abnormal placenta labyrinth morphology ( J:374598 )

• at E9.5, placentas exhibit multiple labyrinth zone defects

abnormal trophoblast layer morphology ( J:374598 )

• at E9.5, the Tfeb+ labyrinth trophoblast layer fails to expand, remaining a thin layer

decreased spongiotrophoblast size ( J:374598 )

• at E9.5, placentas show a reduced Tpbpa+ spongiotrophoblast layer

abnormal visceral yolk sac morphology ( J:374598 )

• at E9.5, when dissected intact, most homozygous embryos show yolk sac defects

abnormal placenta development ( J:374598 )

• at E9.5, Gcm1+ chorioallantoic branching is severely impaired

abnormal chorioallantoic fusion ( J:374598 )

• at E9.5, one of 4 homozygous embryos show chorioallantoic attachment; however, less allantoic mesoderm is observed, and the resulting interface fails to expand as widely as in controls

failure of chorioallantoic fusion ( J:374598 )

• at E9.5, three of 4 homozygous embryos show failure of chorioallantoic attachment; allantoic mesoderm is present adjacent to the chorion, but the attachment is weak and easily disrupted during dissection

abnormal heart development ( J:374598 )

• at E9.5, most homozygous embryos show abnormal cardiac development

• however, all homozygous embryos analyzed at E9.5 show ACTA2/SMA staining in cardiac tissue

incomplete rostral neuropore closure ( J:374598 )

• by E9.5, most homozygous embryos have failed to close the cranial neural tube

abnormal head shape ( J:374598 )

• by E9.5, nearly all homozygous embryos have a profoundly abnormal head shape

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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