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| Caption | Almost all AlleleSymbol(MGI:6388376|0)/Chp1em1(IMPC)Tcp (Chp1-/-) embryos display delay at E8.5 and a majority also display an abnormal allantois which is blebby at the tip and irregularly shaped such as the one pictured here. By E9.5 all Chp1-/- mutants are delayed, none have turned appropriately and almost all have profoundly abnormal head shape and most have failed to close the cranial neural tube. In a minority of E9.5 mutants the allantois appears to have attached but in all cases this attachment was fragile and easily disturbed during dissection. Most E9.5 Chp1-/-display abnormal heart development and when dissected intact, the majority appeared to have yolk sac defects. | ||||
| Copyright | This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/30/2025 MGI 6.24 |
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