Phenotypes associated with this allele

• Allele Symbol: Tph2^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6386305
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tph2^em1(IMPC)Mbp/Tph2^em1(IMPC)Mbp	C57BL/6N-Tph2^em1(IMPC)Mbp/MbpMmucd	MGI:7267115
ht2	Tph2^em1(IMPC)Mbp/Tph2^+	C57BL/6N-Tph2^em1(IMPC)Mbp/MbpMmucd	MGI:7267114

Genotype
MGI:7267115

hm1

• Allelic Composition: Tph2^em1(IMPC)Mbp/Tph2^em1(IMPC)Mbp
• Genetic Background: C57BL/6N-Tph2^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Tph2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

♀

IMPC - UCD

decreased locomotor activity ( J:211773 )

♀

IMPC - UCD

no spontaneous movement ( J:211773 )

IMPC - UCD

cardiovascular system

abnormal placenta vasculature ( J:211773 )

♂

IMPC - UCD

embryo

abnormal placenta morphology ( J:211773 )

♂

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

♂

IMPC - UCD

endocrine/exocrine glands

abnormal ovary morphology ( J:211773 )

♀

IMPC - UCD

enlarged ovary ( J:211773 )

♀

IMPC - UCD

growth/size/body

enlarged ovary ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♂

IMPC - UCD

hematopoietic system

increased eosinophil cell number ( J:211773 )

♀

IMPC - UCD

abnormal spleen morphology ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

♂

IMPC - UCD

immune system

increased eosinophil cell number ( J:211773 )

♀

IMPC - UCD

abnormal spleen morphology ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

♂

IMPC - UCD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

♂

IMPC - UCD

reproductive system

abnormal ovary morphology ( J:211773 )

♀

IMPC - UCD

enlarged ovary ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:7267114

ht2

• Allelic Composition: Tph2^em1(IMPC)Mbp/Tph2⁺
• Genetic Background: C57BL/6N-Tph2^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Tph2

behavior/neurological

decreased startle reflex ( J:211773 )

♂

IMPC - UCD

no spontaneous movement ( J:211773 )

IMPC - UCD

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

IMPC - UCD

embryo

abnormal placenta morphology ( J:211773 )

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

IMPC - UCD

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

enlarged testis ( J:211773 )

♂

IMPC - UCD

growth/size/body

enlarged kidney ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♀

IMPC - UCD

liver/biliary system

abnormal liver morphology ( J:211773 )

♀

IMPC - UCD

small liver ( J:211773 )

♀

IMPC - UCD

nervous system

abnormal brain morphology ( J:211773 )

♀

IMPC - UCD

increased brain size ( J:211773 )

♀

IMPC - UCD

increased prepulse inhibition ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♀

IMPC - UCD

enlarged kidney ( J:211773 )

♀

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

enlarged testis ( J:211773 )

♂

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

♀

IMPC - UCD

abnormal retina vasculature morphology ( J:211773 )

IMPC - UCD

persistence of hyaloid vascular system ( J:211773 )

IMPC - UCD