Analysis Tools
nervous system
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• clusters of vacuolated structures in the thalamus, inferior colliculus, and medulla
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astrocytosis
(
J:281235
)
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• mild in the cortex, hippocampus, thalamus, hypothalamus, caudate nucleus, deep cerebellar nuclei, and pons
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• occasionally in the deep cerebellar nuclei and medulla
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• Purkinje cell axonal swelling with swollen mitochondria in the deep cerebellar nuclei
• progressive formation at 6 weeks and 4 months
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• reduced
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behavior/neurological
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N |
• mice exhibit normal cued memory
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• impaired performance in a Morris water maze during training
• impaired retention of spatial memory
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• mice spend less time exploring the alternate arms of a Y-maze compared with wild-type mice
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• impaired performance on a rotarod at 11 to 13 months, but not younger
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homeostasis/metabolism
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• impaired autophagic flux in neurons
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cellular
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• impaired autophagic flux in neurons
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