Phenotypes associated with this allele

• Allele Symbol: Lbr^em1(IMPC)Tcp
• Allele Name: endonuclease-mediated mutation 1, The Centre for Phenogenomics
• Allele ID: MGI:6383386
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lbr^em1(IMPC)Tcp/Lbr^em1(IMPC)Tcp	C57BL/6N-Lbr^em1(IMPC)Tcp/Tcp	MGI:6731366

Genotype
MGI:6731366

hm1

• Allelic Composition: Lbr^em1(IMPC)Tcp/Lbr^em1(IMPC)Tcp
• Genetic Background: C57BL/6N-Lbr^em1(IMPC)Tcp/Tcp

Data Sources

IMPC Data for Lbr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

♀

IMPC - TCP

impaired pupillary reflex ( J:211773 )

IMPC - TCP

decreased grip strength ( J:211773 )

♀

IMPC - TCP

decreased locomotor activity ( J:211773 )

♀

IMPC - TCP

cardiovascular system

shortened PR interval ( J:211773 )

♀

IMPC - TCP

craniofacial

abnormal cranium morphology ( J:211773 )

♀

IMPC - TCP

endocrine/exocrine glands

small seminal vesicle ( J:211773 )

♂

IMPC - TCP

small testis ( J:211773 )

♂

IMPC - TCP

growth/size/body

decreased body length ( J:211773 )

♀

IMPC - TCP

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211773 )

♀

IMPC - TCP

increased neutrophil cell number ( J:211773 )

♀

IMPC - TCP

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - TCP

increased monocyte cell number ( J:211773 )

♀

IMPC - TCP

homeostasis/metabolism

decreased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - TCP

immune system

increased neutrophil cell number ( J:211773 )

♀

IMPC - TCP

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - TCP

increased monocyte cell number ( J:211773 )

♀

IMPC - TCP

enlarged lymph nodes ( J:211773 )

♂

IMPC - TCP

integument

abnormal coat/ hair morphology ( J:211773 )

IMPC - TCP

absent vibrissae ( J:211773 )

♀

IMPC - TCP

abnormal skin morphology ( J:211773 )

♀

IMPC - TCP

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - TCP

abnormal forelimb morphology ( J:211773 )

♂

IMPC - TCP

short tibia ( J:211773 )

♀

IMPC - TCP

abnormal tail morphology ( J:211773 )

♀

IMPC - TCP

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

♂

IMPC - TCP

nervous system

decreased prepulse inhibition ( J:211773 )

♀

IMPC - TCP

reproductive system

small seminal vesicle ( J:211773 )

♂

IMPC - TCP

small testis ( J:211773 )

♂

IMPC - TCP

skeleton

abnormal cranium morphology ( J:211773 )

♀

IMPC - TCP

short tibia ( J:211773 )

♀

IMPC - TCP

abnormal bone structure ( J:211773 )

♀

IMPC - TCP

decreased bone mineral content ( J:211773 )

♀

IMPC - TCP

decreased bone mineral density ( J:211773 )

♀

IMPC - TCP

vision/eye

impaired pupillary reflex ( J:211773 )

IMPC - TCP