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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sdc2tm1c(KOMP)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6364846
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sdc2tm1c(KOMP)Wtsi/Sdc2tm1c(KOMP)Wtsi
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: C57BL/6J * C57BL/6N MGI:6364849
cn2
 		Sdc2tm1c(KOMP)Wtsi/Sdc2tm1c(KOMP)Wtsi
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 		involves: C57BL/6J * C57BL/6N * CBA MGI:6364848


Genotype
MGI:6364849
cn1
Allelic
Composition		 Sdc2tm1c(KOMP)Wtsi/Sdc2tm1c(KOMP)Wtsi
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc2tm1c(KOMP)Wtsi mutation (0 available); any Sdc2 mutation (16 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased angiogenesis ( J:276769 )
• induced by VEGFA165 in retinal from tamoxifen-treated mice in a cornea pocket assay model
• however, response to FGF2 is normal

homeostasis/metabolism
decreased susceptibility to injury ( J:276769 )
• reduced blood flow after common femoral artery ligation with reduced perfused arterial vessels and vessel size in tamoxifen-treated mice




Genotype
MGI:6364848
cn2
Allelic
Composition		 Sdc2tm1c(KOMP)Wtsi/Sdc2tm1c(KOMP)Wtsi
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc2tm1c(KOMP)Wtsi mutation (0 available); any Sdc2 mutation (16 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:276769 )
• reduced postnatal vessel outgrowth with reduced branching in tamoxifen-treated mice
decreased angiogenesis ( J:276769 )
• reduced in the retina of tamoxifen-treated mice with reduced number of tip cells
• however, vessel pruning is normal

vision/eye
abnormal retina vasculature morphology ( J:276769 )
• reduced postnatal vessel outgrowth with reduced branching in tamoxifen-treated mice

cellular
decreased endothelial cell proliferation ( J:276769 )
• in tamoxifen-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory