About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Terb2em2Leim
endonuclease-mediated mutation 2, Ming Lei
MGI:6362936
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Terb2em2Leim/Terb2em2Leim C57BL/6-Terb2em2Leim MGI:6363009


Genotype
MGI:6363009
hm1
Allelic
Composition		 Terb2em2Leim/Terb2em2Leim
Genetic
Background		 C57BL/6-Terb2em2Leim
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terb2em2Leim mutation (0 available); any Terb2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis ( J:270644 )
• arrest at pachytene-like stage
arrest of male meiosis ( J:270644 )
• in prophase I
abnormal synaptonemal complex ( J:270644 )
• partially synapsed lateral elements

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:270644 )
• impaired homologous recombination and persistent double-strand breaks in spermatocytes

cellular
abnormal female meiosis ( J:270644 )
• arrest at pachytene-like stage
arrest of male meiosis ( J:270644 )
• in prophase I
abnormal synaptonemal complex ( J:270644 )
• partially synapsed lateral elements
abnormal double-strand DNA break repair ( J:270644 )
• impaired homologous recombination and persistent double-strand breaks in spermatocytes

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory