Phenotypes associated with this allele

• Allele Symbol: Terb2^em1Leim
• Allele Name: endonuclease-mediated mutation 1, Ming Lei
• Allele ID: MGI:6362934
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Terb2^em1Leim/Terb2^em1Leim	C57BL/6-Terb2^em1Leim	MGI:6363007

Genotype
MGI:6363007

hm1

• Allelic Composition: Terb2^em1Leim/Terb2^em1Leim
• Genetic Background: C57BL/6-Terb2^em1Leim

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:270644 )

♂

increased male germ cell apoptosis ( J:270644 )

♂

absent ovarian follicles ( J:270644 )

♀

small ovary ( J:270644 )

♀

decreased ovary weight ( J:270644 )

♀

small testis ( J:270644 )

♂

decreased testis weight ( J:270644 )

♂

abnormal female meiosis ( J:270644 )

♀ • arrest at pachytene-like stage

arrest of male meiosis ( J:270644 )

♂ • in prophase I

abnormal synaptonemal complex ( J:270644 )

♀ • partially synapsed lateral elements

female infertility ( J:270644 )

♀

male infertility ( J:270644 )

♂

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:270644 )

♂ • impaired homologous recombination and persistent double-strand breaks in spermatocytes

cellular

azoospermia ( J:270644 )

♂

increased male germ cell apoptosis ( J:270644 )

♂

abnormal double-strand DNA break repair ( J:270644 )

♂ • impaired homologous recombination and persistent double-strand breaks in spermatocytes

endocrine/exocrine glands

absent ovarian follicles ( J:270644 )

♀

small ovary ( J:270644 )

♀

decreased ovary weight ( J:270644 )

♀

small testis ( J:270644 )

♂

decreased testis weight ( J:270644 )

♂