Phenotypes associated with this allele

• Allele Symbol: Dusp26^em1Jhxia
• Allele Name: endonuclease-mediated mutation 1, Jiahong Xia
• Allele ID: MGI:6361751
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dusp26^em1Jhxia/Dusp26^em1Jhxia Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: C57BL/6 * DBA	MGI:6361914

Genotype
MGI:6361914

cn1

• Allelic Composition: Dusp26^em1Jhxia/Dusp26^em1Jhxia; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:279111 )

• in mice fed a high-fat diet or a high-fat and high-cholesterol diet

increased circulating glucose level ( J:279111 )

• more so than controls in mice fed a high-fat diet

increased fasting circulating glucose level ( J:279111 )

• in mice fed a high-fat and high-cholesterol diet

increased circulating alanine transaminase level ( J:279111 )

• in mice fed a high-fat diet

increased circulating aspartate transaminase level ( J:279111 )

• in mice fed a high-fat diet

impaired glucose tolerance ( J:279111 )

• more so than controls in mice fed a high-fat diet

• in mice fed a high-fat and high-cholesterol diet

decreased liver glycogen level ( J:279111 )

• in mice fed a high-fat diet

insulin resistance ( J:279111 )

• more so than controls in mice fed a high-fat diet

increased liver cholesterol level ( J:279111 )

• in mice fed a high-fat diet or a high-fat and high-cholesterol diet

increased liver free fatty acids level ( J:279111 )

• in mice fed a high-fat diet

increased liver triglyceride level ( J:279111 )

• in mice fed a high-fat diet or a high-fat and high-cholesterol diet

liver/biliary system

abnormal liver morphology ( J:279111 )

• increased susceptibility to hepatic steatosis in mice fed a high-fat diet or a high-fat and high-cholesterol diet

increased liver weight ( J:279111 )

• in mice fed a high-fat diet or a high-fat and high-cholesterol diet

decreased liver glycogen level ( J:279111 )

• in mice fed a high-fat diet

increased liver cholesterol level ( J:279111 )

• in mice fed a high-fat diet or a high-fat and high-cholesterol diet

increased liver free fatty acids level ( J:279111 )

• in mice fed a high-fat diet

increased liver triglyceride level ( J:279111 )

• in mice fed a high-fat diet or a high-fat and high-cholesterol diet

liver fibrosis ( J:279111 )

• in mice fed a high-fat and high-cholesterol diet

growth/size/body

increased susceptibility to diet-induced obesity ( J:279111 )

• in mice fed a high-fat diet or a high-fat and high-cholesterol diet

increased liver weight ( J:279111 )

• in mice fed a high-fat diet or a high-fat and high-cholesterol diet