All Phenotypes Zc3h12c<tm2c(EUCOMM)Hmgu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zc3h12c^{tm2c(EUCOMM)Hmgu}
targeted mutation 2c, Helmholtz Zentrum Muenchen GmbH
MGI:6359731

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N	MGI:6359746
cn2	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N	MGI:6359749
cn3	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Tg(Cd4-cre)1Cwi/0	involves: 129S4/SvJaeSor * C57BL/6N * DBA/2	MGI:6359748

Allelic Composition	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (16 available); any Lyz2 mutation (40 available)
Zc3h12c^{tm2c(EUCOMM)Hmgu} mutation (0 available); any Zc3h12c mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:277714 )

• in the lymph node

increased immature B cell number ( J:277714 )

• in the spleen

increased marginal zone B cell number ( J:277714 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:277714 )

• in the lymph node

increased effector memory CD8-positive, alpha-beta T cell number ( J:277714 )

• in the spleen

enlarged lymph nodes ( J:277714 )

• as in knock-out mice

hematopoietic system

increased B cell number ( J:277714 )

• in the lymph node

increased immature B cell number ( J:277714 )

• in the spleen

increased marginal zone B cell number ( J:277714 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:277714 )

• in the lymph node

increased effector memory CD8-positive, alpha-beta T cell number ( J:277714 )

• in the spleen

Allelic Composition	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Zc3h12c^{tm2c(EUCOMM)Hmgu} mutation (0 available); any Zc3h12c mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:277714 )

N	• mice exhibit normal B cell numbers and lymph node size

Allelic Composition	Zc3h12c^{tm2c(EUCOMM)Hmgu}/Zc3h12c^{tm2c(EUCOMM)Hmgu} Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (12 available)
Zc3h12c^{tm2c(EUCOMM)Hmgu} mutation (0 available); any Zc3h12c mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:277714 )

N	• mice exhibit normal T cell viability and numbers and lymph node size

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/07/2025 MGI 6.24