Phenotypes associated with this allele

• Allele Symbol: Mia2^tm1Zhxu
• Allele Name: targeted mutation 1, Zhiheng Xu
• Allele ID: MGI:6358033
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mia2^tm1Zhxu/Mia2^tm1Zhxu Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129 * C57BL/6 * DBA	MGI:6358148

Genotype
MGI:6358148

cn1

• Allelic Composition: Mia2^tm1Zhxu/Mia2^tm1Zhxu; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129 * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:268333 )

• mice are smaller 1 month after birth

enlarged liver ( J:268333 )

• livers are enlarged in 2-week old mice

homeostasis/metabolism

decreased circulating cholesterol level ( J:268333 )

• total plasma cholesterol levels are reduced in P35 and P90 mice fed normally or under fasting conditions

decreased circulating triglyceride level ( J:268333 )

• total plasma triglyceride levels are reduced in P35 and P90 mice fed normally or under fasting conditions

• however, P35 and P90 mice exhibit normal albumin and glucose levels under fasting conditions

increased liver cholesterol level ( J:268333 )

• total cholesterol levels in the liver are increased in P35 mice fed a normal chow diet or when fasted for 16 hours

• however liver total cholesterol levels are similar to controls in P90 fasted mice

increased liver triglyceride level ( J:268333 )

• liver triglyceride levels are increased in in P35 mice fed a normal chow diet or when fasted for 16 hours and in P90 fasted mice

liver/biliary system

abnormal liver morphology ( J:268333 )

• 30% of livers develop nodular morphology with lipid storage disease-like structures in 1 year old mice

enlarged liver ( J:268333 )

• livers are enlarged in 2-week old mice

increased liver cholesterol level ( J:268333 )

• total cholesterol levels in the liver are increased in P35 mice fed a normal chow diet or when fasted for 16 hours

• however liver total cholesterol levels are similar to controls in P90 fasted mice

increased liver triglyceride level ( J:268333 )

• liver triglyceride levels are increased in in P35 mice fed a normal chow diet or when fasted for 16 hours and in P90 fasted mice

abnormal hepatocyte morphology ( J:268333 )

• size and number of lipid droplets are increased in hepatocytes

• hepatocytes exhibit distended endoplasmic reticulum and particles with density similar to lipid droplets are seen in the lumen

• small particles with density similar to lipid droplets are not seen within the membrane-bound secretory vesicles of the Golgi apparatus as in wild-type hepatocytes

hepatic steatosis ( J:268333 )

• fatty liver is seen as early as P1 and through adulthood

• size and number of lipid droplets are increased in hepatocytes

pale liver ( J:268333 )

• livers are pale in 2-week old mice

abnormal liver physiology ( J:268333 )

• quantitative lipidomic and proteomic analyses indicate impaired secretion of different types of lipids and proteins, including VLDL, from the liver