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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx1em1Lhc
endonuclease-mediated mutation 1, Lucio H Castilla
MGI:6356886
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Runx1em1Lhc/Runx1em1Lhc C57BL/6N-Runx1em1Lhc MGI:8314954
ht2
 		Runx1em1Lhc/Runx1+ C57BL/6N-Runx1em1Lhc MGI:8314955
ht3
 		Runx1em1Lhc/Runx1tm1Spe involves: 129S4/SvJae * C57BL/6N MGI:8314956
cn4
 		Nrastm1Tyj/Nras+
Runx1em1Lhc/Runx1tm1Spe
Tg(Mx1-cre)1Cgn/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6N * CBA/J MGI:8314958
cn5
 		Nrastm1Tyj/Nras+
Runx1em1Lhc/Runx1+
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA/J MGI:8314959


Genotype
MGI:8314954
hm1
Allelic
Composition		 Runx1em1Lhc/Runx1em1Lhc
Genetic
Background		 C57BL/6N-Runx1em1Lhc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1em1Lhc mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:8314955
ht2
Allelic
Composition		 Runx1em1Lhc/Runx1+
Genetic
Background		 C57BL/6N-Runx1em1Lhc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1em1Lhc mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
impaired DNA repair ( J:380963 )
• in hematopoietic progenitor cells from bone marrow subjected to irradiation

hematopoietic system
increased common myeloid progenitor cell number ( J:380963 )
• in bone marrow at age 12 weeks
increased bone marrow cell number ( J:380963 )
• increased serum levels at age 12 weeks
decreased leukocyte cell number ( J:380963 )
• reduced circulation of mainly B and T cells
increased hematopoietic stem cell number ( J:380963 )
• increased number of hematopoietic stem and progenitor cells (HSPCs) in bone marrow at age 12 weeks

homeostasis/metabolism
impaired DNA repair ( J:380963 )
• in hematopoietic progenitor cells from bone marrow subjected to irradiation
increased chemokine level ( J:380963 )
• higher CCL5, CXCL10 and other chemokine serum levels at age 12 weeks

immune system
decreased leukocyte cell number ( J:380963 )
• reduced circulation of mainly B and T cells
increased chemokine level ( J:380963 )
• higher CCL5, CXCL10 and other chemokine serum levels at age 12 weeks
increased CXCL10 secretion ( J:380963 )
• increased serum levels at age 12 weeks

neoplasm
neoplasm ( J:380963 )
N
• no tumors by age 78 weeks




Genotype
MGI:8314956
ht3
Allelic
Composition		 Runx1em1Lhc/Runx1tm1Spe
Genetic
Background		 involves: 129S4/SvJae * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1em1Lhc mutation (0 available); any Runx1 mutation (34 available)
Runx1tm1Spe mutation (1 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased classified tumor incidence ( J:380963 )
• full penetrance myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), myeloid leukemia (ML), T-cell leukemia; median latency 37 weeks




Genotype
MGI:8314958
cn4
Allelic
Composition		 Nrastm1Tyj/Nras+
Runx1em1Lhc/Runx1tm1Spe
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6N * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrastm1Tyj mutation (1 available); any Nras mutation (40 available)
Runx1em1Lhc mutation (0 available); any Runx1 mutation (34 available)
Runx1tm1Spe mutation (1 available); any Runx1 mutation (34 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased classified tumor incidence ( J:380963 )
• full penetrance myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), T-cell leukemia; median latency 14.7 weeks




Genotype
MGI:8314959
cn5
Allelic
Composition		 Nrastm1Tyj/Nras+
Runx1em1Lhc/Runx1+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrastm1Tyj mutation (1 available); any Nras mutation (40 available)
Runx1em1Lhc mutation (0 available); any Runx1 mutation (34 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased classified tumor incidence ( J:380963 )
• full penetrance myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), T-cell leukemia; median latency 54 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory