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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Magi1tm1Itl
targeted mutation 1, Ingenious Targeting Laboratory
MGI:6356800
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Magi1tm1Itl/Magi1tm1Itl B6.Cg-Magi1tm1Itl MGI:6358153
cx2
 		Magi1tm1Itl/Magi1tm1Itl
Nphs1tm1Rkl/Nphs1+ 		involves: 129/Sv * C57BL/6 MGI:6379273
cx3
 		Kirrel1tm1.2Geno/Kirrel1+
Magi1tm1Itl/Magi1tm1Itl 		involves: C57BL/6 MGI:6379280


Genotype
MGI:6358153
hm1
Allelic
Composition		 Magi1tm1Itl/Magi1tm1Itl
Genetic
Background		 B6.Cg-Magi1tm1Itl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magi1tm1Itl mutation (0 available); any Magi1 mutation (174 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:237632 )
• No significant histological changes or proteinuria were detected in null mice up to an age of 2 years.
• did not show glomerular pathological changes (0 of 25 mice)
• Background Sensitivity: did not show increased susceptibility to adriamycin nephropathy compared with wild type cotrol on a resistant C57Bl/6 genetic background




Genotype
MGI:6379273
cx2
Allelic
Composition		 Magi1tm1Itl/Magi1tm1Itl
Nphs1tm1Rkl/Nphs1+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magi1tm1Itl mutation (0 available); any Magi1 mutation (174 available)
Nphs1tm1Rkl mutation (1 available); any Nphs1 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased urine protein level ( J:237632 )
• At approximately 1 year of age

renal/urinary system
increased urine protein level ( J:237632 )
• At approximately 1 year of age
abnormal podocyte morphology ( J:237632 )
• glomeruli affected showed podocyte swelling
abnormal podocyte slit diaphragm morphology ( J:237632 )
• glomeruli affected showed severe podocyte effacement by electron microscopy analyses
decreased podocyte number ( J:237632 )
• glomeruli affected showed podocyte loss
glomerulosclerosis ( J:237632 )
• focal segmental glomerulosclerosis (FSGS) at approximately 1 year of age in 4 of 23 mice
• FSGS lesions were present in 2?8% of glomeruli in affected mice
• FSGS was of variable intensity, ranging from small focal lesions with characteristic synechia formation to more globally appearing lesions




Genotype
MGI:6379280
cx3
Allelic
Composition		 Kirrel1tm1.2Geno/Kirrel1+
Magi1tm1Itl/Magi1tm1Itl
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kirrel1tm1.2Geno mutation (0 available); any Kirrel1 mutation (194 available)
Magi1tm1Itl mutation (0 available); any Magi1 mutation (174 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:237632 )
• No significant histological changes or proteinuria were detected (0 pf 20 mice)
• did not show glomerular pathological changes (0 pf 20 mice)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory