Analysis Tools
mortality/aging
| N |
• mice survive to adulthood
|
hematopoietic system
|
• mild
|
|
Allele Symbol Allele Name Allele ID |
Cdk5rap3tm1c(EUCOMM)Hmgu targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH MGI:6294784 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survive to adulthood
|
|
• mild
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice began to die after weaning
• however, supplementation with glucose after weaning rescues come mortality
|
|
• defective at 1 months with disorganized tubular structures extending away from portal tracts
• however, parenchyma organization at 0.5 months is normal
|
|
• smaller cell area at 1 month of age
• reduced hepatocyte maturation
|
|
• hepatocytes exhibit perturbed endoplasmic reticulum homeostasis (increased ER stress and activated unfolded protein response) compared with control cells
|
|
• at 1 month of age in fasted and fed mice
|
|
• however, serum aspartate transaminase levels are normal
|
|
• from 1 week of age
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survive to adulthood
|
| N |
• mice exhibit normal liver histology
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/30/2024 MGI 6.23 |
|
|
|
||