All Phenotypes Kctd5<em1(IMPC)J> MGI Mouse

abnormal vitelline vasculature morphology ( J:374598 )

• by E9.5, some homozygous embryos exhibit yolk sac vascularization defects

abnormal heart morphology ( J:374598 )

• at E8.5, a minority of homozygous embryos exhibit abnormal hearts

abnormal heart looping ( J:374598 )

• at E9.5, some homozygous embryos show an abnormally looped heart

enlarged heart ( J:374598 )

• at E9.5, homozygous embryos exhibit enlarged hearts

• by E10.5, all are dying or resorbed with enlarged hearts

abnormal pharyngeal arch morphology ( J:374598 )

• by E9.5, most homozygous embryos exhibit branchial arch defects, likely related to abnormal hearts

abnormal head shape ( J:374598 )

• at E8.5, a minority of homozygous embryos exhibit an abnormal head shape

abnormal vitelline vasculature morphology ( J:374598 )

• by E9.5, some homozygous embryos exhibit yolk sac vascularization defects

abnormal pharyngeal arch morphology ( J:374598 )

• by E9.5, most homozygous embryos exhibit branchial arch defects, likely related to abnormal hearts

incomplete embryo turning ( J:374598 )

• by E9.5, homozygous embryos exhibit incomplete turning

embryonic growth retardation ( J:374598 )

• at E8.5, a minority of homozygous embryos are delayed

• however, all three germ layers are present at E8.5 and germ layer patterning is normal at E9.5

incomplete rostral neuropore closure ( J:374598 )

• by E9.5, a minority of homozygous embryos show partially open posterior cranial neural tube

abnormal placenta labyrinth morphology ( J:374598 )

• at E9.5, all placentas exhibit multiple labyrinth zone defects

abnormal trophoblast layer morphology ( J:374598 )

• at E9.5, the Tfeb+ labyrinth trophoblast layer fails to expand

decreased spongiotrophoblast size ( J:374598 )

• at E9.5, all placentas exhibit a diminished Tpbpa+ spongiotrophoblast layer

abnormal visceral yolk sac morphology ( J:374598 )

• at E8.5, a minority of homozygous embryos exhibit abnormal yolk sacs

abnormal placenta development ( J:374598 )

• at E9.5, Gcm1+ chorioallantoic branching is severely impaired

abnormal chorioallantoic fusion ( J:374598 )

• at E9.5, all placentas exhibit an abnormal chorioallantoic interface (reduction in allantoic mesoderm)

enlarged heart ( J:374598 )

• at E9.5, homozygous embryos exhibit enlarged hearts

• by E10.5, all are dying or resorbed with enlarged hearts

abnormal head shape ( J:374598 )

• at E8.5, a minority of homozygous embryos exhibit an abnormal head shape

embryonic growth retardation ( J:374598 )

• at E8.5, a minority of homozygous embryos are delayed

• however, all three germ layers are present at E8.5 and germ layer patterning is normal at E9.5

cardiac edema ( J:374598 )

• by E9.5, homozygous embryos exhibit slight epicardial edema

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality during organogenesis, complete penetrance ( J:374598 )

• homozygous embryos are present in Mendelian ratios at E8.5 and E9.5 but absent at E12.5; most/all homozygous embryos are resorbing or dying by E10.5

incomplete rostral neuropore closure ( J:374598 )

• by E9.5, a minority of homozygous embryos show partially open posterior cranial neural tube

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/30/2025 MGI 6.24