Phenotype Image Detail

Image

Caption

At E8.5, Kctd5^em1(IMPC)J/Kctd5^em1(IMPC)J (Kctd5-/-) embryos are mainly normal. A minority display abnormal head shape, abnormal YS, abnormal heart or are delayed. By E9.5 Kctd5-/- embryos display slight epicardial edema, enlarged hearts and incomplete turning. Branchial arch defects are also noted in a majority, but likely related to the abnormal hearts. A minority of embryos display partially open posterior cranial neural tube and some have yolk sac vascularization defects. By E10.5 all Kctd5-/- are dying or resorbed with enlarged hearts.

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598

Associated
Alleles

Symbol	Name
Kctd5^em1(IMPC)J	potassium channel tetramerisation domain containing 5; endonuclease-mediated mutation 1, Jackson

Associated
Genotypes

Allelic Composition	Genetic Background
Kctd5^em1(IMPC)J/Kctd5^em1(IMPC)J	C57BL/6NJ-Kctd5^em1(IMPC)J/Mmjax

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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