Phenotypes associated with this allele

• Allele Symbol: Got2^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6276937
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Got2^em1(IMPC)Mbp/Got2^em1(IMPC)Mbp	C57BL/6NCrl-Got2^em1(IMPC)Mbp/Mmucd	MGI:6408409
ht2	Got2^em1(IMPC)Mbp/Got2^+	C57BL/6NCrl-Got2^em1(IMPC)Mbp/Mmucd	MGI:6461303

Genotype
MGI:6408409

hm1

• Allelic Composition: Got2^em1(IMPC)Mbp/Got2^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Got2^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Got2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Got2^em1(IMPC)Mbp/Got2^em1(IMPC)Mbp embryos display abnormal head shape and some have abnormal allantois, are developmentally delayed at E9.5, with incomplete turning and defects/delay in cranial neural tube closure, and abnormal heart shape.

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - UCD

abnormal vitelline vasculature morphology ( J:211773 )

IMPC - UCD

abnormal heart morphology ( J:211773 )

IMPC - UCD

abnormal heart looping ( J:374598 )

• at E9.5, some homozygous embryos show inappropriate heart looping

abnormal heart shape ( J:374598 )

• by E9.5, many homozygous embryos exhibit an abnormal heart shape

enlarged heart ( J:374598 )

• at E9.5, some homozygous embryos exhibit an enlarged heart

hemorrhage ( J:211773 )

IMPC - UCD

craniofacial

abnormal pharyngeal arch morphology ( J:211773 )

♂

IMPC - UCD

abnormal head shape ( J:374598 )

• at E8.5 and E9.5, most homozygous embryos exhibit an abnormal head shape

embryo

abnormal vitelline vasculature morphology ( J:211773 )

IMPC - UCD

abnormal pharyngeal arch morphology ( J:211773 )

♂

IMPC - UCD

abnormal embryo turning ( J:211773 )

IMPC - UCD

incomplete embryo turning ( J:374598 )

• by E9.5, all homozygous embryos exhibit incomplete turning

embryonic growth retardation ( J:211773 , J:374598 )

IMPC - UCD (J:211773)

MGI

• by E9.5, all homozygous embryos are developmentally delayed (J:374598)

• however, all three germ layers are present at E8.5 and germ layer patterning is normal at E9.5 (J:374598)

abnormal neural tube morphology ( J:211773 )

IMPC - UCD

abnormal neural tube closure ( J:211773 )

IMPC - UCD

delayed rostral neuropore closure ( J:374598 )

• by E9.5, most homozygous embryos display defects/delays in cranial neural tube closure

incomplete rostral neuropore closure ( J:374598 )

• by E9.5, most homozygous embryos display defects/delays in cranial neural tube closure

abnormal allantois morphology ( J:374598 )

• at E8.5, some homozygous embryos display an abnormal allantois

abnormal placenta labyrinth morphology ( J:374598 )

• at E9.5, placentas exhibit multiple labyrinth zone defects

abnormal trophoblast layer morphology ( J:374598 )

• at E9.5, the Tfeb+ labyrinth trophoblast layer fails to expand, remaining a thin layer

decreased spongiotrophoblast size ( J:374598 )

• at E9.5, placentas exhibit a diminished Tpbpa+ spongiotrophoblast layer

abnormal visceral yolk sac morphology ( J:211773 )

IMPC - UCD

abnormal placenta development ( J:374598 )

• at E9.5, Gcm1+ chorioallantoic branching is severely impaired

abnormal chorioallantoic fusion ( J:374598 )

• at E9.5, placentas exhibit an abnormal chorioallantoic interface (reduction in allantoic mesoderm)

growth/size/body

enlarged heart ( J:374598 )

• at E9.5, some homozygous embryos exhibit an enlarged heart

abnormal head shape ( J:374598 )

• at E8.5 and E9.5, most homozygous embryos exhibit an abnormal head shape

embryonic growth retardation ( J:211773 , J:374598 )

IMPC - UCD (J:211773)

MGI

• by E9.5, all homozygous embryos are developmentally delayed (J:374598)

• however, all three germ layers are present at E8.5 and germ layer patterning is normal at E9.5 (J:374598)

mortality/aging

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - UCD

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

embryonic lethality during organogenesis, complete penetrance ( J:374598 )

• homozygous embryos are present in Mendelian ratios at E8.5 and E9.5 but absent at E12.5; all homozygous embryos are resorbing or dying by E10.5

nervous system

abnormal neural tube morphology ( J:211773 )

IMPC - UCD

abnormal neural tube closure ( J:211773 )

IMPC - UCD

delayed rostral neuropore closure ( J:374598 )

• by E9.5, most homozygous embryos display defects/delays in cranial neural tube closure

incomplete rostral neuropore closure ( J:374598 )

• by E9.5, most homozygous embryos display defects/delays in cranial neural tube closure

abnormal forebrain development ( J:211773 )

IMPC - UCD

abnormal hindbrain development ( J:211773 )

IMPC - UCD

abnormal midbrain development ( J:211773 )

IMPC - UCD

Genotype
MGI:6461303

ht2

• Allelic Composition: Got2^em1(IMPC)Mbp/Got2⁺
• Genetic Background: C57BL/6NCrl-Got2^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Got2

digestive/alimentary system

enlarged cecum ( J:211773 )

♂

IMPC - UCD

embryo

embryonic growth retardation ( J:211773 )

IMPC - UCD

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

hematopoietic system

enlarged spleen ( J:211773 )

♀

IMPC - UCD

small spleen ( J:211773 )

IMPC - UCD

immune system

enlarged spleen ( J:211773 )

♀

IMPC - UCD

small spleen ( J:211773 )

IMPC - UCD

renal/urinary system

small kidney ( J:211773 )

♀

IMPC - UCD

vision/eye

cataract ( J:211773 )

♀

IMPC - UCD

abnormal vitreous body morphology ( J:211773 )

♀

IMPC - UCD