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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Carm1tm1.1Mtb
targeted mutation 1.1, Mark T Bedford
MGI:6276271
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Carm1tm1.1Mtb/Carm1tm1.1Mtb
Tg(Stra8-icre)1Reb/0 		involves: 129 * C57BL/6J * FVB/NJ MGI:6283447


Genotype
MGI:6283447
cn1
Allelic
Composition		 Carm1tm1.1Mtb/Carm1tm1.1Mtb
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129 * C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Carm1tm1.1Mtb mutation (0 available); any Carm1 mutation (93 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm midpiece morphology ( J:265753 )
• percentage of sperm with a crooked/bent midpiece is significantly increased
abnormal sperm head morphology ( J:265753 )
• most cauda epididymal sperm exhibit deformed head morphology
absent sperm head ( J:265753 )
• percentage of acephalic/headless sperm is significantly increased
abnormal spermatid morphology ( J:265753 )
• a significant drop in the number of late stage spermatids is observed, starting from step 7
decreased male germ cell number ( J:265753 )
• a significant drop in the number of late stage spermatids is observed, starting from step 7
oligozoospermia ( J:265753 )
• at 6 weeks of age, average sperm count in the cauda epididymis is severely reduced
asthenozoospermia ( J:265753 )
• a dramatic decrease in sperm motility is observed
decreased testis weight ( J:265753 )
• a slight but significant decrease in testis weight is observed at 3 months of age
• however, testis size and weight are normal at 6 weeks of age
abnormal spermiogenesis ( J:265753 )
• development of late stage haploid spermatids is impaired
abnormal cauda epididymis morphology ( J:265753 )
• cauda epididymis shows an accumulation of immature germ cells and aberrant sperm
decreased litter size ( J:265753 )
• subfertile males produced an average of 1.7 pups per litter
male infertility ( J:265753 )
• half of the 2-month-old males examined were completely sterile
reduced male fertility ( J:265753 )
• half of the 2-month-old males examined produced very small litters

cellular
abnormal sperm midpiece morphology ( J:265753 )
• percentage of sperm with a crooked/bent midpiece is significantly increased
abnormal sperm head morphology ( J:265753 )
• most cauda epididymal sperm exhibit deformed head morphology
absent sperm head ( J:265753 )
• percentage of acephalic/headless sperm is significantly increased
abnormal spermatid morphology ( J:265753 )
• a significant drop in the number of late stage spermatids is observed, starting from step 7
decreased male germ cell number ( J:265753 )
• a significant drop in the number of late stage spermatids is observed, starting from step 7
oligozoospermia ( J:265753 )
• at 6 weeks of age, average sperm count in the cauda epididymis is severely reduced
asthenozoospermia ( J:265753 )
• a dramatic decrease in sperm motility is observed

endocrine/exocrine glands
decreased testis weight ( J:265753 )
• a slight but significant decrease in testis weight is observed at 3 months of age
• however, testis size and weight are normal at 6 weeks of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory