Carm1^tm1.1Mtb
Targeted Allele Detail

Summary

• Symbol: Carm1^tm1.1Mtb
• Name: coactivator-associated arginine methyltransferase 1; targeted mutation 1.1, Mark T Bedford
• MGI ID: MGI:6276271
• Synonyms: Carm1^loxP
• Gene: Carm1 Location: Chr9:21458163-21500763 bp, + strand Genetic Position: Chr9, Syntenic
• Alliance: Carm1^tm1.1Mtb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269584
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette was inserted upstream of two exons encoding a portion of the cofactor binding domain (amino acids 117-187). Additionally, the inserted neo cassette and the two exons were flanked by a single loxP sites. Flp mediated recombination removed the neo cassette. (J:83623, J:269584)

Expression

In Mice Carrying this Mutation:	23 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Carm1 Mutation: 93 strains or lines available

References

• Original: J:269584 Hupalowska A, et al., CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development. Cell. 2018 Dec 13;175(7):1902-1916.e13
• All: 4 reference(s)