Analysis Tools
cardiovascular system
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• at E9.5, approximately half of homozygous embryos show abnormal cardiac development
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• at E10.5
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craniofacial
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IMPC - JAX
(J:211773)
MGI
• at E9.5, almost half of homozygous embryos exhibit branchial arch/pouch abnormalities
(J:374598)
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• by E9.5, most homozygous embryos exhibit an abnormal head shape
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embryo
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• homozygous embryos are normal at E8.5 but either dying or severely dysmorphic by E10.5
• however, germ layer patterning is normal at E9.5 and E10.5
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IMPC - JAX
(J:211773)
MGI
• at E9.5, almost half of homozygous embryos exhibit branchial arch/pouch abnormalities
(J:374598)
|
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IMPC - JAX
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• by E9.5, a minority of homozygous embryos exhibit incomplete closure of the cranial neural tube
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• at E9.5, almost half of homozygous embryos exhibit branchial arch/pouch abnormalities
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• at E10.5, placentas exhibit multiple labyrinth zone defects
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• at E10.5, the Tfeb+ labyrinth trophoblast layer is markedly reduced
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• at E10.5, placentas exhibit an expanded Tpbpa+ (trophoblast specific protein alpha-positive) spongiotrophoblast layer
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• at E9.5, abnormal cardiac development is often accompanied by yolk sac defects
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• placentas are properly developed at E9.5 but show multiple defects at E10.5
• at E10.5, chorioallantoic branching is nearly absent, as Gcm1 (glial cells missing homolog 1) expression is sparse and remains at the chorioallantoic interface
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growth/size/body
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• by E9.5, most homozygous embryos exhibit an abnormal head shape
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homeostasis/metabolism
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• at E10.5
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mortality/aging
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IMPC - JAX
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IMPC - JAX
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• homozygous embryos are present in expected Mendelian ratios at E8.5 and E9.5 but absent at E12.5; all homozygous embryos are dying or severely dysmorphic at E10.5
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nervous system
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IMPC - JAX
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• by E9.5, a minority of homozygous embryos exhibit incomplete closure of the cranial neural tube
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