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| Caption | Arpc1aem1(IMPC)J/Arpc1aem1(IMPC)J (-/-) embryos are normal at E8.5. By E9.5 a minority are indistinguishable from littermates but most have abnormal head shape, a minority with incomplete closure of the cranial neural tube. Branchial arch/pouch abnormalities are apparent in almost half of the E9.5 mutants. Approximately half have abnormal cardiac development (including that presented here) and this is often accompanied by yolk sac defects. By E10.5 the mutants are either dying or severely dysmorphic such as that pictured here. | ||||
| Copyright | This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/30/2025 MGI 6.24 |
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