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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxo43tm1.2Kald
targeted mutation 1.2, Philipp Kaldis
MGI:6201342
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fbxo43tm1.2Kald/Fbxo43tm1.2Kald involves: 129 * C57BL/6 * FVB/N * SJL MGI:6201524
cn2
 		Fbxo43tm1.1Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:6201521
cn3
 		Cdk1tm3Kald/Cdk1+
Fbxo43tm1.2Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:6201527


Genotype
MGI:6201524
hm1
Allelic
Composition		 Fbxo43tm1.2Kald/Fbxo43tm1.2Kald
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo43tm1.2Kald mutation (0 available); any Fbxo43 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal oocyte morphology ( J:251984 )
• with a germinal vesicle-like structure with chromatin (likely decondensed)
azoospermia ( J:251984 )
• absence of spermatid at p63 and sperm in epididymis at P120
abnormal female meiosis ( J:251984 )
• arrested in metaphase meiosis II
parthenogenesis ( J:251984 )
• parthenogenetic divisions in oocytes of 2 of 11 mice
arrest of male meiosis ( J:251984 )
• in prophase in meiosis I
• however, meiotic recombination and resolution of double-strand breaks is normal
increased male germ cell apoptosis ( J:251984 )
• at stage XII (pachytene/diplotene)

neoplasm
neoplasm ( J:251984 )
N
• despite parthenogenetic oocyte divisions, female mice do not develop ovarian cancer

endocrine/exocrine glands

cellular
abnormal oocyte morphology ( J:251984 )
• with a germinal vesicle-like structure with chromatin (likely decondensed)
azoospermia ( J:251984 )
• absence of spermatid at p63 and sperm in epididymis at P120
abnormal female meiosis ( J:251984 )
• arrested in metaphase meiosis II
parthenogenesis ( J:251984 )
• parthenogenetic divisions in oocytes of 2 of 11 mice
arrest of male meiosis ( J:251984 )
• in prophase in meiosis I
• however, meiotic recombination and resolution of double-strand breaks is normal
increased male germ cell apoptosis ( J:251984 )
• at stage XII (pachytene/diplotene)




Genotype
MGI:6201521
cn2
Allelic
Composition		 Fbxo43tm1.1Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo43tm1.1Kald mutation (0 available); any Fbxo43 mutation (29 available)
Fbxo43tm1.2Kald mutation (0 available); any Fbxo43 mutation (29 available)
Gt(ROSA)26Sortm1(cre/ERT)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:251984 )
• at stage XII (pachytene/diplotene) in tamoxifen-treated mice
male infertility ( J:251984 )
• in tamoxifen-treated mice

cellular
increased male germ cell apoptosis ( J:251984 )
• at stage XII (pachytene/diplotene) in tamoxifen-treated mice




Genotype
MGI:6201527
cn3
Allelic
Composition		 Cdk1tm3Kald/Cdk1+
Fbxo43tm1.2Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk1tm3Kald mutation (0 available); any Cdk1 mutation (21 available)
Fbxo43tm1.2Kald mutation (0 available); any Fbxo43 mutation (29 available)
Gt(ROSA)26Sortm1(cre/ERT)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:251984 )
• within 4 to 5 days after treatment with tamoxifen at around age P21

reproductive system
azoospermia ( J:251984 )
• after treatment with tamoxifen at around age P21
arrest of male meiosis ( J:251984 )
• early in diplotene with some progression into metaphase
increased male germ cell apoptosis ( J:251984 )
• after treatment with tamoxifen at around age P21

cellular
azoospermia ( J:251984 )
• after treatment with tamoxifen at around age P21
arrest of male meiosis ( J:251984 )
• early in diplotene with some progression into metaphase
increased male germ cell apoptosis ( J:251984 )
• after treatment with tamoxifen at around age P21




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory