Fbxo43^tm1.2Kald
Targeted Allele Detail

Summary

• Symbol: Fbxo43^tm1.2Kald
• Name: F-box protein 43; targeted mutation 1.2, Philipp Kaldis
• MGI ID: MGI:6201342
• Synonyms: Emi2^null
• Gene: Fbxo43 Location: Chr15:36150206-36165030 bp, - strand Genetic Position: Chr15, 14.46 cM
• Alliance: Fbxo43^tm1.2Kald page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251984
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in testes. (J:251984)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxo43 Mutation: 29 strains or lines available

References

• Original: J:251984 Gopinathan L, et al., Emi2 Is Essential for Mouse Spermatogenesis. Cell Rep. 2017 Jul 18;20(3):697-708
• All: 1 reference(s)