Analysis Tools
cardiovascular system
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• by E9.5, many homozygous embryos exhibit abnormal heart morphology
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craniofacial
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• by E9.5, nearly all homozygous embryos exhibit an abnormal head shape
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embryo
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• by E9.5, most homozygous embryos are unturned or exhibit incomplete turning
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• by E9.5, most homozygous embryos are unturned or exhibit incomplete turning
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• at E8.5, homozygous embryos appear relatively normal but are often delayed relative to control littermates
(J:374598)
• by E9.5, most homozygous embryos are delayed, some more severely than others
(J:374598)
• however, all three germ layers are present at E8.5 and germ layer patterning is normal at E9.5
(J:374598)
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IMPC - JAX
(J:211773)
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• by E9.5, nearly all homozygous embryos exhibit incomplete cranial neural tube closure, possibly due to the developmental delay
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• by E9.5, approximately half of homozygous embryos show mild caudal neural tube kinks
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• both at E8.5 and E9.5, a few homozygous embryos exhibit a circular tissue above their head folds, likely resulting from inappropriate resolution of the amnionic cavity
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• at E9.5, placentas exhibit multiple labyrinth zone defects
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• at E9.5, the Tfeb+ labyrinth trophoblast layer fails to expand, remaining a thin layer
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• at E9.5, placentas exhibit a diminished Tpbpa+ spongiotrophoblast layer
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• by E9.5, a minority of homozygous embryos exhibit abnormal yolk sacs
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• at E9.5, Gcm1+ chorioallantoic branching is severely impaired
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• at E9.5, placentas exhibit an abnormal chorioallantoic interface with a reduction in allantoic mesoderm and limited interface expansion
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growth/size/body
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• by E9.5, nearly all homozygous embryos exhibit an abnormal head shape
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• at E8.5, homozygous embryos appear relatively normal but are often delayed relative to control littermates
(J:374598)
• by E9.5, most homozygous embryos are delayed, some more severely than others
(J:374598)
• however, all three germ layers are present at E8.5 and germ layer patterning is normal at E9.5
(J:374598)
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IMPC - JAX
(J:211773)
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mortality/aging
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IMPC - JAX
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IMPC - JAX
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• homozygous embryos are present in near Mendelian ratios at E8.5 and E9.5 but absent at E12.5
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nervous system
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• by E9.5, nearly all homozygous embryos exhibit incomplete cranial neural tube closure, possibly due to the developmental delay
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• by E9.5, approximately half of homozygous embryos show mild caudal neural tube kinks
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