All Phenotypes Stt3b<em1(IMPC)J> MGI Mouse

abnormal heart morphology ( J:374598 )

• by E10.5, all homozygous embryos show abnormal heart morphology, including cardiac and/or pericardial edema

pericardial edema ( J:374598 )

• at E9.5, homozygous embryos occasionally exhibit pericardial edema but most remain otherwise normal

• by E10.5, all homozygous embryos display cardiac and/or pericardial edema

abnormal pharyngeal arch morphology ( J:374598 )

• by E10.5, all homozygous embryos show abnormal branchial arches

abnormal head shape ( J:374598 )

• by E10.5, all homozygous embryos show abnormal head shape

abnormal pharyngeal arch morphology ( J:374598 )

• by E10.5, all homozygous embryos show abnormal branchial arches

embryonic growth retardation ( J:211773 , J:374598 )

IMPC - JAX (J:211773)

MGI

• by E10.5, many homozygous embryos are developmentally delayed relative to control littermates (J:374598)

• however, homozygous embryos are normal at E8.5; by E9.5, germ layer patterning is normal, and almost all homozygous embryos have completed turning (J:374598)

decreased embryo size ( J:374598 )

• at E9.5, homozygous embryos are often small but still within the expected range

abnormal placenta labyrinth morphology ( J:374598 )

• at E9.5 and E10.5, placentas exhibit multiple labyrinth zone defects

abnormal trophoblast layer morphology ( J:374598 )

• at E9.5, the Tfeb+ labyrinth trophoblast layer is of normal thickness, but Tfeb signal intensity appears elevated, suggesting an increased density of Tfeb+ cells

• by E10.5, the Tfeb+ labyrinth trophoblast layer is slightly reduced in thickness, but signal intensity remains elevated

abnormal visceral yolk sac morphology ( J:374598 )

• by E10.5, all homozygous embryos show abnormal yolk sac morphology

abnormal placenta development ( J:374598 )

• Gcm1+ chorioallantoic branching is reduced at E9.5 and severely impaired by E10.5

abnormal head shape ( J:374598 )

• by E10.5, all homozygous embryos show abnormal head shape

embryonic growth retardation ( J:211773 , J:374598 )

IMPC - JAX (J:211773)

MGI

• by E10.5, many homozygous embryos are developmentally delayed relative to control littermates (J:374598)

• however, homozygous embryos are normal at E8.5; by E9.5, germ layer patterning is normal, and almost all homozygous embryos have completed turning (J:374598)

decreased embryo size ( J:374598 )

• at E9.5, homozygous embryos are often small but still within the expected range

pericardial edema ( J:374598 )

• at E9.5, homozygous embryos occasionally exhibit pericardial edema but most remain otherwise normal

• by E10.5, all homozygous embryos display cardiac and/or pericardial edema

cardiac edema ( J:374598 )

• at E9.5, homozygous embryos occasionally exhibit cardiac edema but most remain otherwise normal

• by E10.5, all homozygous embryos display cardiac and/or pericardial edema

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality during organogenesis, complete penetrance ( J:374598 )

• homozygous embryos are present in Mendelian ratios at E8.5-E10.5; all homozygous embryos recovered at E11.5 are dying/undergoing resorption

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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