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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mtcl1tm1.1Atsuz
targeted mutation 1.1, Atsushi Suzuki
MGI:6154024
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mtcl1tm1.1Atsuz/Mtcl1tm1.1Atsuz involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl MGI:6154043


Genotype
MGI:6154043
cn1
Allelic
Composition		 Mtcl1tm1.1Atsuz/Mtcl1tm1.1Atsuz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtcl1tm1.1Atsuz mutation (0 available); any Mtcl1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Purkinje cell axon morphology ( J:253309 )
• reduced length of Ank3-positive region in Purkinje cell axons at age 3 weeks
abnormal Purkinje cell dendrite morphology ( J:253309 )
• dilation of distal dendrites at age 2 months
abnormal axon initial segment morphology ( J:253309 )
• irregular AIS morphology in Purkinje cells at age 2 months
axonal spheroids ( J:253309 )
• Purkinje cell axonal swellings at age 2 months

behavior/neurological
abnormal motor coordination/balance ( J:253309 )
• starting at age 3-4 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory