Mtcl1^tm1.1Atsuz
Targeted Allele Detail

Summary

• Symbol: Mtcl1^tm1.1Atsuz
• Name: microtubule crosslinking factor 1; targeted mutation 1.1, Atsushi Suzuki
• MGI ID: MGI:6154024
• Synonyms: 1110012J17Rik(loxP), Mtcl1^flox
• Gene: Mtcl1 Location: Chr17:66643977-66756745 bp, - strand Genetic Position: Chr17, 35.3 cM
• Alliance: Mtcl1^tm1.1Atsuz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253309
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked by loxP sites. An FRT site flanked neomycin resistance gene cassette was inserted into intron 1. The neo cassette was removed through subsequent flp-mediated recombination. This creates a conditional-ready allele with exon 1 floxed. (J:253309)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtcl1 Mutation: 54 strains or lines available

References

• Original: J:253309 Satake T, et al., MTCL1 plays an essential role in maintaining Purkinje neuron axon initial segment. EMBO J. 2017 May 2;36(9):1227-1242
• All: 1 reference(s)