Phenotypes associated with this allele

• Allele Symbol: Zc3h4^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6152686
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zc3h4^em1(IMPC)Mbp/Zc3h4^em1(IMPC)Mbp	C57BL/6NCrl-Zc3h4^em1(IMPC)Mbp/Mmucd	MGI:6263905
ht2	Zc3h4^em1(IMPC)Mbp/Zc3h4^+	C57BL/6NCrl-Zc3h4^em1(IMPC)Mbp/Mmucd	MGI:6370456

Genotype
MGI:6263905

hm1

• Allelic Composition: Zc3h4^em1(IMPC)Mbp/Zc3h4^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Zc3h4^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Zc3h4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

absent inner cell mass proliferation ( J:279207 )

• blastocysts fail to form typical outgrowth colonies after 3 days in culture

embryo

absent inner cell mass proliferation ( J:279207 )

• blastocysts fail to form typical outgrowth colonies after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• blastocysts fail to hatch from the zona pellucida after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - UCD

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• normal looking blastocysts are present at slightly lower than expected Mendelian ratios at E3.5 (19% versus 25%); excess resorption sites but no homozygous embryos are observed at E7.5

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - UCD

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:6370456

ht2

• Allelic Composition: Zc3h4^em1(IMPC)Mbp/Zc3h4⁺
• Genetic Background: C57BL/6NCrl-Zc3h4^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Zc3h4

cardiovascular system

hemorrhage ( J:211773 )

IMPC - UCD

embryo

spina bifida ( J:211773 )

IMPC - UCD

growth/size/body

microcephaly ( J:211773 )

IMPC - UCD

homeostasis/metabolism

increased circulating serum albumin level ( J:211773 )

♂

IMPC - UCD

integument

abnormal coat/hair pigmentation ( J:211773 )

♀

IMPC - UCD

limbs/digits/tail

polydactyly ( J:211773 )

IMPC - UCD

syndactyly ( J:211773 )

IMPC - UCD

nervous system

spina bifida ( J:211773 )

IMPC - UCD

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

♀

IMPC - UCD

reproductive system

abnormal epididymis morphology ( J:211773 )

♂

IMPC - UCD

enlarged epididymis ( J:211773 )

♂

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

♀

IMPC - UCD

microphthalmia ( J:211773 )

IMPC - UCD

anophthalmia ( J:211773 )

IMPC - UCD