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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cnot1tm1Tya
targeted mutation 1, Tadashi Yamamoto
MGI:6151143
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cnot1tm1Tya/Cnot1tm1Tya
Tg(Ckmm-cre)5Khn/0 		involves: C57BL/6 * FVB MGI:6151160
cn2
 		Atg7tm1Tchi/Atg7tm1Tchi
Cnot1tm1Tya/Cnot1tm1Tya
Tg(Ckmm-cre)5Khn/0 		involves: C57BL/6NCrlj * CBA/JNCrlj * FVB MGI:6151162


Genotype
MGI:6151160
cn1
Allelic
Composition		 Cnot1tm1Tya/Cnot1tm1Tya
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot1tm1Tya mutation (0 available); any Cnot1 mutation (161 available)
Tg(Ckmm-cre)5Khn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system

muscle




Genotype
MGI:6151162
cn2
Allelic
Composition		 Atg7tm1Tchi/Atg7tm1Tchi
Cnot1tm1Tya/Cnot1tm1Tya
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (3 available); any Atg7 mutation (52 available)
Cnot1tm1Tya mutation (0 available); any Cnot1 mutation (161 available)
Tg(Ckmm-cre)5Khn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
cardiac muscle necrosis ( J:260012 )
• not as severe as in Cnot1tm1Tya/Cnot1tm1Tya Tg(Ckmm-cre)5Khn mice
decreased cardiac muscle contractility ( J:260012 )
• not as severe as in Cnot1tm1Tya/Cnot1tm1Tya Tg(Ckmm-cre)5Khn mice

muscle
cardiac muscle necrosis ( J:260012 )
• not as severe as in Cnot1tm1Tya/Cnot1tm1Tya Tg(Ckmm-cre)5Khn mice
decreased cardiac muscle contractility ( J:260012 )
• not as severe as in Cnot1tm1Tya/Cnot1tm1Tya Tg(Ckmm-cre)5Khn mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory