Cnot1^tm1Tya
Targeted Allele Detail

Summary

• Symbol: Cnot1^tm1Tya
• Name: CCR4-NOT transcription complex, subunit 1; targeted mutation 1, Tadashi Yamamoto
• MGI ID: MGI:6151143
• Synonyms: Cnot1^flox
• Gene: Cnot1 Location: Chr8:96446079-96534092 bp, - strand Genetic Position: Chr8, 47.18 cM
• Alliance: Cnot1^tm1Tya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260012
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 21 and 22 were floxed. (J:260012)

Expression

In Mice Carrying this Mutation:	416144 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnot1 Mutation: 161 strains or lines available

References

• Original: J:260012 Yamaguchi T, et al., The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 2018 Feb 6;11(516)
• All: 4 reference(s)