All Phenotypes Cnot3<tm1.1Kjkb> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cnot3^tm1.1Kjkb
targeted mutation 1.1, Keiji Kuba
MGI:6151142

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atg5^tm1Myok/Atg5^tm1Myok Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB	MGI:6151158
cn2	Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:6151150
cn3	Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:6151153
cn4	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB	MGI:6151152
cn5	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N	MGI:6151155
cn6	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf^{Tg(Myh6-cre/Esr1)1Jmk}	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N	MGI:6151156

Allelic Composition	Atg5^tm1Myok/Atg5^tm1Myok Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg5^tm1Myok mutation (3 available); any Atg5 mutation (29 available)
Cnot3^tm1.1Kjkb mutation (0 available); any Cnot3 mutation (34 available)
Tg(Ckmm-cre)5Khn mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal autophagosome formation ( J:260012 )

• impaired autophagosome formation

mortality/aging

premature death ( J:260012 )

cardiovascular system

increased heart weight ( J:260012 )

decreased cardiac muscle contractility ( J:260012 )

prolonged QT interval ( J:260012 )

cellular

abnormal autophagosome formation ( J:260012 )

• impaired autophagosome formation

muscle

decreased cardiac muscle contractility ( J:260012 )

growth/size/body

increased heart weight ( J:260012 )

Allelic Composition	Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot3^tm1.1Kjkb mutation (0 available); any Cnot3 mutation (34 available)
Tg(Ckmm-cre)5Khn mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:260012 )

• all mice die between 3 weeks of age and P30

cardiovascular system

decreased myocardial fiber number ( J:260012 )

cardiac muscle necrosis ( J:260012 )

• focal with reduced cytoplasmic contents and vacuole formation

enlarged heart ( J:260012 )

increased heart weight ( J:260012 )

decreased cardiac muscle contractility ( J:260012 )

irregular heartbeat ( J:260012 )

prolonged QT interval ( J:260012 )

cardiomyopathy ( J:260012 )

muscle

muscle phenotype ( J:260012 )

N	• muscles appear normal

decreased myocardial fiber number ( J:260012 )

cardiac muscle necrosis ( J:260012 )

• focal with reduced cytoplasmic contents and vacuole formation

decreased cardiac muscle contractility ( J:260012 )

cardiomyopathy ( J:260012 )

growth/size/body

enlarged heart ( J:260012 )

increased heart weight ( J:260012 )

Allelic Composition	Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mutation (5 available); any A1cf mutation (37 available)
Cnot3^tm1.1Kjkb mutation (0 available); any Cnot3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:260012 )

• mice treated with tamoxifen at 3 months develop lethal heart failure

cardiovascular system

congestive heart failure ( J:260012 )

• mice treated with tamoxifen at 3 months develop lethal heart failure

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (52 available)
Cnot3^tm1.1Kjkb mutation (0 available); any Cnot3 mutation (34 available)
Tg(Ckmm-cre)5Khn mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal autophagosome formation ( J:260012 )

• impaired autophagosome formation

mortality/aging

premature death ( J:260012 )

• mice survive to 7 weeks after birth

cardiovascular system

cardiovascular system phenotype ( J:260012 )

N	• mice exhibit normal heart weight, cardiac contractility and QT interval

cellular

abnormal autophagosome formation ( J:260012 )

• impaired autophagosome formation

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mutation (5 available); any A1cf mutation (37 available)
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (52 available)
Cnot3^tm1.1Kjkb mutation (0 available); any Cnot3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:260012 )

• tamoxifen-treated mice survive until P40

cardiovascular system

decreased cardiac muscle contractility ( J:260012 )

• not as severe as in mice Cnot3^tm2.1Tya A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mice

muscle

decreased cardiac muscle contractility ( J:260012 )

• not as severe as in mice Cnot3^tm2.1Tya A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mice

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf^{Tg(Myh6-cre/Esr1)1Jmk}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased cardiac muscle contractility ( J:260012 )

• as in mice with one copy of A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}

muscle

decreased cardiac muscle contractility ( J:260012 )

• as in mice with one copy of A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24