Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{em1(CAG-TMEM14B,-EGFP)Xqw}
• Allele Name: endonuclease-mediated mutation 1, Xiaoqun Wang
• Allele ID: MGI:6121115
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^em1(CAG-TMEM14B,-EGFP)Xqw/Gt(ROSA)26Sor^+ Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:6121121

Genotype
MGI:6121121

cn1

• Allelic Composition: Gt(ROSA)26Sor^{em1(CAG-TMEM14B,-EGFP)Xqw}/Gt(ROSA)26Sor⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:253976 )

• cortical sulci and gyri in newborn (P0) mice

abnormal cortical intermediate zone morphology ( J:253976 )

• increased proliferation and shortened cell cycle of NP cells in SVZ

• doubling of oblique cell divisions (14% to 28%) of ventricular radial glia (vRG) cells in SVZ

• increased subventricular zone (SVZ) in E15.5 embryos

• two-fold increase (15% to 30%) in number of Pax6+ neural progenitor (NP) cells in SVZ

• significant increase in Pax6+ outer radial glia (oRG) cells visualized by phospho-Vimentin staining in SVZ

• increase in Sox2+ and Tbr2+ intermediate progenitor (IP) cells in SVZ

abnormal cortical plate morphology ( J:253976 )

• thickened in P0 mice

increased brain size ( J:253976 )

• in newborn (P0) mice

• increased cortical area, volume and perimeter, anterior-posterior and mediolateral size

abnormal neocortex morphology ( J:253976 )

• increased proliferation and shortened cell cycle of NP cells in SVZ

• doubling of oblique cell divisions (14% to 28%) of ventricular radial glia (vRG) cells in subventricular zone (SVZ)

• cortical sulci and gyri in newborn (P0) mice

• proliferation of NP cells in ventricular zone (VZ)

• increase in Sox2+ and Tbr2+ intermediate progenitor (IP) cells in SVZ

• significant increase in Pax6+ outer radial glia (oRG) cells visualized by phospho-Vimentin staining in SVZ

• Pax6+ progenitor cells expanded radially toward intermediate zone (IZ)

• two-fold increase (15% to 30%) in number of Pax6+ neural progenitor (NP) cells in SVZ

• age E15.5 embryos

increased neocortex size ( J:253976 )

• thickening due to increased subventricular zone (SVZ) in E15.5 embryos

• thickened cortical plate (CP) in P0 mice

• increase in Satb2+ (upper layer II/III marker) cells in P0 mice

• increase in Ctip2+ (deep layer V marker) cells in P0 mice

• increase in Foxp2+ (deep layer VI marker) cells in P0 mice

thickened cerebral cortex ( J:253976 )

• in newborn (P0) mice

• increased cortical area, volume and perimeter, anterior-posterior and mediolateral size

abnormal embryonic/fetal subventricular zone morphology ( J:253976 )

• increased subventricular zone (SVZ) in E15.5 embryos

• two-fold increase (15% to 30%) in number of Pax6+ neural progenitor (NP) cells

• significant increase in Pax6+ outer radial glia (oRG) cells visualized by phospho-Vimentin staining

• increase in Sox2+ and Tbr2+ intermediate progenitor (IP) cells

• increased proliferation and shortened cell cycle of NP cells

• doubling of oblique cell divisions (14% to 28%) of ventricular radial glia (vRG) cells