All Phenotypes Rab11fip1<tm1.1Jicn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rab11fip1^tm1.1Jicn
targeted mutation 1.1, Jim C Norman
MGI:6113874

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras⁺ Rab11fip1^tm1.1Jicn/Rab11fip1^tm1.1Jicn Tg(Pdx1-cre)6Tuv/0 Trp53^tm2.1Tyj/Trp53⁺	involves: 129S4/SvJae * FVB/N	MGI:6113915

Allelic Composition	Kras^tm4Tyj/Kras⁺ Rab11fip1^tm1.1Jicn/Rab11fip1^tm1.1Jicn Tg(Pdx1-cre)6Tuv/0 Trp53^tm2.1Tyj/Trp53⁺
Genetic Background	involves: 129S4/SvJae * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Rab11fip1^tm1.1Jicn mutation (0 available); any Rab11fip1 mutation (41 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm2.1Tyj mutation (2 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:244261 )

N	• phenotypes are relative to the control KPC (Kras^G12D/+, p53^R172H/+, Pdx1-Cre) PDAC (pancreatic adenocarcinoma) model mice • size of PDAC primary tumors same as control

decreased metastatic potential ( J:244261 )

• significantly reduced number of detectable PDAC metastases to liver, lung and other tissues

• reduced migration of PDAC cells in vitro

mortality/aging

mortality/aging ( J:244261 )

N	• survival same as control

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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